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Biology of human sodium glucose transporters.
TLDR
A personal review of advances in the genetics, molecular biology, biochemistry, biophysics, and structure of SGLTs, including cotransporters for sugars, anions, vitamins, and short-chain fatty acids. Expand
Thyroid Na+/I− Symporter
TLDR
The rat thyroid Na+/I− symporter was expressed in Xenopus laevis oocytes and characterized using electrophysiological, tracer uptake, and electron microscopic methods to propose an ordered simultaneous transport mechanism in which the binding of Na+ to NIS occurs first. Expand
Relaxation kinetics of the Na+/glucose cotransporter.
TLDR
Charge transfer measurements give insight into the partial reactions of the Na+/glucose cotransporter, and, combined with genetic engineering of the protein, provide a powerful tool for studying transport mechanisms. Expand
Inhibition of Gap Junction Hemichannels by Chloride Channel Blockers
TLDR
It is concluded that some chloride-channel blockers inhibit lens-connexin hemichannels by acting on a site accessible only from the extracellular space, and that drug-hemichannel interaction involves a high-affinity site other than the Ca2+ binding site. Expand
Transport Mechanism of the Cloned Potato H+/Sucrose Cotransporter StSUT1*
TLDR
The transport mechanism of the potato StSUT1 H+/sucrose cotransporter expressed in Xenopus oocytes was investigated using the 2-electrode voltage clamp and radiotracer flux methods and a kinetic model for sucrose transport was formed. Expand
Regulation of Na+/Glucose Cotransporter Expression by Protein Kinases in Xenopus laevis Oocytes*
TLDR
The regulation of SGLT1 expression in oocytes by protein kinases occurs mainly by regulated endo- and exocytosis; it is independent of consensus phosphorylation sites in the transporter; and the effect of a given kinase depends upon the actual sequence of the cotransporter expressed. Expand
Mechanisms of the Human Intestinal H-coupled Oligopeptide Transporter hPEPT1 (*)
TLDR
The hPEPT1 cDNA cloned from human intestine encodes a H/oligopeptide cotransporter that exhibits H-dependent transient currents with characteristics similar to those of Na-coupled transporters. Expand
Low and high affinity amino acid H+-cotransporters for cellular import of neutral and charged amino acids.
TLDR
A detailed comparison of the properties by electrophysiology after heterologous expression in Xenopus oocytes shows that, although capable of recognizing and transporting a wide spectrum of amino acids, individual AAPs differ with respect to specificity, and in vivo competition shows that the capability to transport basic amino acids in planta might be overruled by excess amides and acidic amino acid in the apoplasm. Expand
Electrogenic properties of the cloned Na+/glucose cotransporter: II. A transport model under nonrapid equilibrium conditions
TLDR
The electrical properties of the cloned Na+/glucose cotransporter are found to be adequately described by this 6-state kinetic model, and the main voltage effect is on carrier translocation. Expand
Surprising versatility of Na+-glucose cotransporters: SLC5.
TLDR
SLC5 is an ancient gene family with 11 members in the human genome that has diverse, multiple functions ranging from actively transporting solutes, ions, and water, to channeling water and urea, to sensing glucose in cholinergic neurons. Expand
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