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Animal chlamydioses and zoonotic implications.
The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation.
The complete genome sequence was determined and shows a high level of conservation in both sequence and overall gene content in comparison to other Chlamydiaceae, suggesting that the genetic basis of niche adaptation of this species is distinct from those previously proposed for other chlamydial species. Expand
Recent developments in the laboratory diagnosis of chlamydial infections.
An overview on methodologies and technologies used currently in diagnosis of chlamydial infections with emphasis on recently developed tests is given, and a combination of a specific real-time PCR assay and a microarray test for chlamydiae is proposed as an alternative reference standard to isolation by cell culture. Expand
Vaccination against chlamydial infections of man and animals.
Much research still needs to be done to improve the delivery of plasmid DNA, as well as the expression and presentation of antigens to ensure that effective immune responses are induced, particularly in humans and large animals than in mice. Expand
The Major Outer Membrane Protein of Chlamydia psittaci Functions as a Porin-Like Ion Channel
Primary structure analysis by circular dichroism now reveals that MOMP purified from Chlamydiaspecies has a predominantly β-sheet content, which is also typical of bacterial porins, and may be a route by which Chlamydia can take advantage of host nucleoside triphosphates and explain why some anti-MOMP antibodies neutralize infection. Expand
Seroprevalence of chlamydial infection in cattle in Ireland.
The results suggest the prevalence of chlamydial infection is low in cattle in Ireland. Expand
Chlamydial Infection in sheep: Immune Control versus Fetal Pathology
A reclassification of the order Chlamydiales and its taxa based mainly on phylogenetic analyses of the 16S and 23S rRNA genes, but also on corroborating genetic and phenotypic information is shown. Expand
Antibody Responses to Recombinant Protein Fragments of the Major Outer Membrane Protein and Polymorphic Outer Membrane Protein POMP90 in Chlamydophila abortus-Infected Pregnant Sheep
Earlier detection of infection will allow appropriate control measures to be taken to reduce environmental contamination, thus limiting the spread of infection, financial losses, and the possible risks of zoonotic transmission to humans. Expand
Molecular detection of Chlamydophila abortus in post-abortion sheep at oestrus and subsequent lambing.
The results, although not discounting the possibility of a chronic low level persistent infection in post-abortion ewes, suggest that the low levels of chlamydial DNA detected during the periovulation period and at lambing do not significantly impact on the epidemiology of EAE. Expand
Immunoelectron microscopic localisation of the OMP90 family on the outer membrane surface of Chlamydia psittaci.
The putative outer membrane location of the OMP90 (formerly POMP) family from the ovine abortion strain of Chlamydia psittaci was investigated by immunoelectron microscopy, showing the importance of these proteins as protective antigen candidates. Expand