Immunobiology of eosinophils.
- G. Gleich, D. Loegering
- MedicineAnnual Review of Immunology
In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417.
- P. Haluska, J. Carboni, C. Erlichman
- Biology, ChemistryCancer Research
BMS-554417 is a member of a novel class of IGF-IR/insulin receptor inhibitors that have potential clinical applications because of their antiproliferative and proapoptotic activity in vitro and in vivo.
MCL-1 as a Buffer for Proapoptotic BCL-2 Family Members during TRAIL-induced Apoptosis
- X. Meng, Sun-Hee Lee, S. Kaufmann
- Biology, ChemistryJournal of Biological Chemistry
- 12 October 2007
Observations suggest a model in which Mcl-1 confers TRAIL resistance by serving as a buffer for Bak, Bim, and Puma, but also identify sorafenib as a potential modulator of TRAIL sensitivity.
Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases.
- R. L. Barker, D. Loegering, R. Ten, K. Hamann, L. Pease, G. Gleich
- Biology, ChemistryJournal of Immunology
- 1 August 1989
ECP and EDN are derived from a common ancestral ribonuclease gene and that ECP has evolved into a potent helminthotoxin similar in some respects to MBP, while losing much of its rib onuclease activity.
Cytotoxic properties of the eosinophil major basic protein.
- G. Gleich, E. Frigas, D. Loegering, D. Wassom, D. Steinmuller
- Biology, MedicineJournal of Immunology
- 1 December 1979
Concentrations of MBP in the toxic range were found in sputa from asthmatics, in pleural fluid and in sera, suggesting the hypothesis that the eosinophil produces damage to cells in disease.
Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease.
- G. Gleich, D. Loegering, M. Bell, J. Checkel, S. Ackerman, D. McKEAN
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 May 1986
Results indicate that EDN and ECP are related proteins and suggest that they derived from genes associated with the RNase family.
Elevated serum levels of the eosinophil granule major basic protein in patients with eosinophilia.
- D. Wassom, D. Loegering, G. Gleich
- Medicine, BiologyJournal of Clinical Investigation
- 1 March 1981
The results indicate that eos inophil granule proteins circulate in blood covalently bound to serum proteins, and that elevated concentrations of serum MBP are present in some diseases associated with eosinophilia.
In vitro killing of microfilariae of Brugia pahangi and Brugia malayi by eosinophil granule proteins.
- K. Hamann, G. Gleich, J. Checkel, D. Loegering, J. Mccall, R. L. Barker
- BiologyJournal of Immunology
- 15 April 1990
All of the eosinophil granule proteins are toxic to mf and they support the hypothesis that eos inophil degranulation causes death of mf in vivo.
IDENTIFICATION OF A MAJOR BASIC PROTEIN IN GUINEA PIG EOSINOPHIL GRANULES
- G. Gleich, D. Loegering, J. Maldonado
- BiologyJournal of Experimental Medicine
- 1 June 1973
These studies indicate that eosinophil granules contain a cationic protein of low molecular weight which lacks peroxidase activity and which accounts for greater than 50% of granule protein.
Comparative toxicity of purified human eosinophil granule cationic proteins for schistosomula of Schistosoma mansoni.
- S. Ackerman, G. Gleich, D. Loegering, B. Richardson, A. Butterworth
- BiologyAmerican Journal of Tropical Medicine and Hygiene
- 1 July 1985
Although ECP is a more potent helminthotoxin for schistosomula than MBP on a molar basis, MBP, by virtue of its abundance in the granule, accounts for the bulk of the toxicity in fractions of acid solubilized granules obtained from eosinophils of patients with marked eos inophilia.