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Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells.
Bcl-2 and related proteins are key regulators of apoptosis or programmed cell death implicated in human disease including cancer. We recently showed that cell-permeable Bcl-2 binding peptides couldExpand
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Strength indices from pQCT imaging predict up to 85% of variance in bone failure properties at tibial epiphysis and diaphysis.
Our primary objective was to validate the Bone Strength Index for compression (BSIC) by determining the amount of variance in failure load and stiffness that was explained by BSIC and bone propertiesExpand
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Mesenchymal progenitor self-renewal deficiency leads to age-dependent osteoporosis in Sca-1/Ly-6A null mice
The cellular and molecular mechanisms that underlie age-dependent osteoporosis, the most common disease in the Western Hemisphere, are poorly understood in part due to the lack of appropriate animalExpand
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Accuracy of pQCT for evaluating the aged human radius: an ashing, histomorphometry and failure load investigation
IntroductionQuantifying the determinants of bone strength is essential to understanding if or how the structure will fail under load. Determining failure requires knowledge of material and geometricExpand
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Tibial geometry is associated with failure load ex vivo: a MRI, pQCT and DXA study
SummaryWe studied the relations between bone geometry and density and the mechanical properties of human cadaveric tibiae. Bone geometry, assessed by MRI and pQCT, and bone density, assessed by DXA,Expand
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Physical activity positively predicts bone architecture and bone strength in adolescent males and females
Aims:  Physical activity (PA) has positive effects on bone accrual and geometry in children during growth. However, we do not know how PA influences adaptations in bone architecture during growth. WeExpand
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alpha 2-HS glycoprotein/fetuin, a transforming growth factor-beta/bone morphogenetic protein antagonist, regulates postnatal bone growth and remodeling.
Soluble transforming growth factor-beta (TGF-beta)/bone morphogenetic protein (BMP)-binding proteins are widely distributed in mammalian tissues and control cytokine access to membrane signalingExpand
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Femoral neck cortical geometry measured with magnetic resonance imaging is associated with proximal femur strength
IntroductionMagnetic resonance imaging (MRI) is a promising medical imaging technique that we used to assess femoral neck cortical geometry.ObjectivesOur primary objective was to assess whetherExpand
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Group mobility based clustering algorithm for mobile ad hoc networks
Recent research activities have recognized the essentiality of node mobility for the creation of stable, scalable and adaptive clusters with good performance in mobile ad hoc networks (MANETs). InExpand
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Elasticity and Viscoelasticity of Human Tibial Cortical Bone Measured by Nanoindentation
Bone is a composite material composed of collagen, carbonated apatite mineral, water, and other non-collagenous proteins. The bone structure inside human body is under constant remodelling. TheExpand
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