• Publications
  • Influence
Respiratory toxicity of multi-wall carbon nanotubes.
Carbon nanotubes focus the attention of many scientists because of their huge potential of industrial applications, but there is a paucity of information on the toxicological properties of thisExpand
  • 966
  • 70
The nanosilica hazard: another variable entity
Silica nanoparticles (SNPs) are produced on an industrial scale and are an addition to a growing number of commercial products. SNPs also have great potential for a variety of diagnostic andExpand
  • 508
  • 27
  • PDF
Clastogenic and aneugenic effects of multi-wall carbon nanotubes in epithelial cells.
Information on the toxicity of carbon nanotubes is still fragmentary but indicates that these particles can induce adverse effects. We previously demonstrated in rats that, when purified multi-wallExpand
  • 266
  • 19
Absence of carcinogenic response to multiwall carbon nanotubes in a 2-year bioassay in the peritoneal cavity of the rat.
Toxicological investigations of carbon nanotubes have shown that they can induce pulmonary toxicity, and similarities with asbestos fibers have been suggested. We previously reported that multiwallExpand
  • 230
  • 16
The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients.
Cyclosporine and tacrolimus are immunosuppressive drugs largely used in renal transplantation. They are characterized by a wide inter-individual variability in their pharmacokinetics with a potentialExpand
  • 401
  • 15
Structural defects play a major role in the acute lung toxicity of multiwall carbon nanotubes: toxicological aspects.
Experimental studies indicate that carbon nanotubes (CNTs) have the potential to induce adverse pulmonary effects, including alveolitis, fibrosis, and genotoxicity in epithelial cells. Here, weExpand
  • 132
  • 13
Update on the genotoxicity and carcinogenicity of cobalt compounds
OBJECTIVE To integrate recent understandings of the mechanisms of genotoxicity and carcinogenicity of the different cobalt compounds. METHOD A narrative review of the studies published since the lastExpand
  • 248
  • 10
  • PDF
CYP3A5 and ABCB1 Polymorphisms and Tacrolimus Pharmacokinetics in Renal Transplant Candidates: Guidelines from an Experimental Study
Genetic polymorphisms in biotransformation enzyme CYP3A5 (6986G > A, CYP3A5*3; 14690A > G, CYP3A5*6) and drug transporter ABCB1 (1236C > T; 2677G > T/A; 3435C > T) are known to influence tacrolimusExpand
  • 154
  • 10
Influence of the route of administration and the chemical form (MnCl2, MnO2) on the absorption and cerebral distribution of manganese in rats
Abstract  The absorption and cerebral distribution of manganese (Mn) have been studied with respect to the route of administration and the chemical form of the Mn compound. Different groups of adultExpand
  • 154
  • 10
Genotoxicity of engineered nanomaterials: A critical review
In view of the fast-growing industrial applications of engineered nanomaterials (ENMs), the evaluation of their genotoxic potential and of their mode of action is a necessity to conduct adequateExpand
  • 183
  • 10