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A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome
TLDR
GSK2586881 was well-tolerated in patients with ARDS, and the rapid modulation of RAS peptides suggests target engagement, although the study was not powered to detect changes in acute physiology or clinical outcomes.
Seasonal Dynamics of Previously Unknown Fungal Lineages in Tundra Soils
TLDR
It is shown that tundra soil microbial biomass reaches its annual peak under snow, and that fungi account for most of the biomass.
A communal catalogue reveals Earth’s multiscale microbial diversity
TLDR
A meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project is presented, creating both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth’s microbial diversity.
Once‐Daily Single‐Inhaler Triple versus Dual Therapy in Patients with COPD
TLDR
Triple therapy with fluticasone furoate, umeclidinium, and vilanterol resulted in a lower rate of moderate or severe COPD exacerbations than flutic asonefuroate–vilanterol or u meclid inium–vilAnterol in this population.
Cultivation of bacteria and fungi.
TLDR
This chapter presents a recipe for a basic basal medium for cultivating microorganisms, and discusses physicochemical factors for cultivation of bacteria and fungi, the fundamentals of the culture of fungi, larger-scale culture of bacteria, and the progress in culturing the uncultured.
Changes in Soil Microbial Community Structure and Function in an Alpine Dry Meadow Following Spring Snow Melt
TLDR
Winter and summer soil respiration responded differently to temperature; at 0 degrees C, winter soils respired at a higher proportion of the 22 degrees C rate than did summer soils.
The unexpected versatility of plants: organic nitrogen use and availability in terrestrial ecosystems
TLDR
This review synthesizes the recent work on availability and plant uptake of amino acids with classic work on ON in soils to predict the ecological implications of ON use by plants given the influence of climatic change and N pollution.
LINKS BETWEEN MICROBIAL POPULATION DYNAMICS AND NITROGEN AVAILABILITY IN AN ALPINE ECOSYSTEM
TLDR
It is concluded that the key event controlling N availability to alpine plants occurs after snow melt, when protein is released from the winter microbial biomass, which provides substrate for soil proteases, which supply plants with amino acids during the growing season.
Viral and microbial community dynamics in four aquatic environments
TLDR
The results suggest a model wherein functionally redundant microbial and viral taxa are cycling at the level of viral genotypes and virus-sensitive microbial strains, which contradicts theoretical models as well as the viral–microbial dynamics observed in simple ecosystems.
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