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Basic local alignment search tool.
A new approach to rapid sequence comparison, basic local alignment search tool (BLAST), directly approximates alignments that optimize a measure of local similarity, the maximal segment pair (MSP)Expand
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
A new criterion for triggering the extension of word hits, combined with a new heuristic for generating gapped alignments, yields a gapped BLAST program that runs at approximately three times the speed of the original. Expand
Improved tools for biological sequence comparison.
  • W. Pearson, D. Lipman
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 April 1988
Three computer programs for comparisons of protein and DNA sequences can be used to search sequence data bases, evaluate similarity scores, and identify periodic structures based on local sequence similarity. Expand
GenBank® is a comprehensive database that contains publicly available nucleotide sequences for over 340 000 formally described species and integrates these records with a variety of other data including taxonomy nodes, genomes, protein structures, and biomedical journal literature in PubMed. Expand
A genomic perspective on protein families.
Comparison of proteins encoded in seven complete genomes from five major phylogenetic lineages and elucidation of consistent patterns of sequence similarities allowed the delineation of 720 clusters of orthologous groups (COGs), which comprise a framework for functional and evolutionary genome analysis. Expand
Rapid and sensitive protein similarity searches.
An algorithm was developed which facilitates the search for similarities between newly determined amino acid sequences and sequences already available in databases and increases sensitivity by giving high scores to those amino acid replacements which occur frequently in evolution. Expand
The Influenza Virus Resource at the National Center for Biotechnology Information
The Influenza Genome Sequencing Project aims to rapidly sequence influenza viruses from samples collected all over the world, and in just over 2 years after the initiation of the project, more than 2,000 complete genomes of influenza viruses A and B had been deposited in GenBank. Expand
GenBank: update
GenBank is a comprehensive database that contains publicly available DNA sequences for more than 140 000 named organisms, obtained primarily through submissions from individual laboratories and batchExpand
Domain enhanced lookup time accelerated BLAST
A new method is described, called domain enhanced lookup time accelerated BLAST (DELTA-BLAST), which searches a database of pre-constructed PSSMs before searching a protein-sequence database, to yield better homology detection, and is a useful program for the detection of remote protein homologs. Expand