Author pages are created from data sourced from our academic publisher partnerships and public sources.
Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 −1082 promoter SNP and its interaction with TNF-α −308 promoter SNP
Ageing is associated with chronic, low grade inflammatory activity leading to long term tissue damage, and systemic chronic inflammation has been found to be related to mortality risk from all causes… Expand
Pathogenesis of autoimmune diseases associated with 8.1 ancestral haplotype: effect of multiple gene interactions.
- G. Candore, D. Lio, G. Colonna Romano, C. Caruso
- Biology, Medicine
- Autoimmunity reviews
- 1 February 2002
Genetic studies have shown that individuals with certain HLA alleles have a higher risk of specific autoimmune disease than those without these alleles. Particularly, the association in all Caucasian… Expand
Innate immunity and inflammation in ageing: a key for understanding age-related diseases
The process of maintaining life for the individual is a constant struggle to preserve his/her integrity. This can come at a price when immunity is involved, namely systemic inflammation. Inflammation… Expand
A genetically determined high setting of TNF-alpha influences immunologic parameters of HLA-B8,DR3 positive subjects: implications for autoimmunity.
The 8.1 ancestral haplotype (AH) is a common Caucasoid haplotype carried by most people who type for HLA-B8,DR3. It seems unique in its association with a wide range of immunopathologic diseases.… Expand
IL-10 and TNF-α polymorphisms in a sample of sicilian patients affected by tuberculosis: implication for ageing and life span expectancy
- L. Scola, A. Crivello, V. Marino, V. Gioia, D. Lio
- Medicine, Biology
- Mechanisms of Ageing and Development
- 1 April 2003
Human longevity seems to be directly correlated with optimal functioning of the immune system, suggesting that some genetic determinants of longevity might reside in those polymorphisms for the… Expand
Inflammation, cytokines, immune response, apolipoprotein E, cholesterol, and oxidative stress in Alzheimer disease: therapeutic implications.
Alzheimer disease (AD) is a heterogeneous and progressive neurodegenerative disease, which in Western society mainly accounts for senile dementia. Today many countries have rising aging populations… Expand
Interleukin-10 promoter polymorphism in sporadic Alzheimer's disease
Proinflammatory cytokines and acute-phase proteins play an important role in Alzheimer's disease (AD) neurodegeneration, and common polymorphisms of genes controlling their high production have been… Expand
Portrait of inflammatory response to ionizing radiation treatment
Ionizing radiation (IR) activates both pro-and anti-proliferative signal pathways producing an imbalance in cell fate decision. IR is able to regulate several genes and factors involved in cell-cycle… Expand
Regulatory cytokine gene polymorphisms and risk of colorectal carcinoma.
- A. Crivello, A. Giacalone, +13 authors S. Palmeri
- Biology, Medicine
- Annals of the New York Academy of Sciences
- 1 November 2006
It is well established that cancer arises in chronically inflamed tissue, and this is particularly notable in the gastrointestinal tract. Classic examples include Helicobacter pylori-associated… Expand
IgG(1) antiendomysium and IgG antitissue transglutaminase (anti-tTG) antibodies in coeliac patients with selective IgA deficiency. Working Groups on Celiac Disease of SIGEP and Club del Tenue.
BACKGROUND In selective IgA deficiency (IgAD), there is no reliable screening test for coeliac disease (CD). AIM To evaluate the usefulness of IgG(1) antiendomysium and IgG antitissue… Expand