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Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
Regulation of the human hsp70 promoter by p53.
It is demonstrated here that p53 both represses transcription from the human hsp70 promoter and also interacts with CBF, suggesting that protein-protein interaction between p53 and specific transcription factors may be an additional mechanism by which p53 regulates gene expression.
Stimulation and inhibition of angiogenesis by placental proliferin and proliferin-related protein.
Analysis of two proteins, proliferin (PLF) and proliferin-related protein (PRP), revealed that they are potent regulators of angiogenesis; PLF stimulated and PRP inhibited endothelial cell migration in cell culture and neovascularization in vivo.
GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo.
GATA-2 and GATA-3 are important in vivo regulators of trophoblast-specific gene expression and placental function, and a difference in the effect of these two factors in regulating the synthesis of related placental hormones is revealed.
Culture pH Affects Expression Rates and Glycosylation of Recombinant Mouse Placental Lactogen Proteins by Chinese Hamster Ovary (CHO) Cells
Glycosylation patterns and specific expression rates of the recombinant protein mouse placental lactogen-I (mPL-I) by Chinese hamster ovary (CHO) cells varied significantly over the extracellular pH…
Nodal regulates trophoblast differentiation and placental development.
Results suggest that nodal may be involved in redirecting trophoblast fate towards the midgestational expansion of the labyrinth region while maintaining the thin layer of trophOBlast giant cells and the underlying layer of spongiotrophoblasts that form the boundary between the maternal and extraembryonic compartments.
GATA factor activity is required for the trophoblast-specific transcriptional regulation of the mouse placental lactogen I gene.
Data indicate that GATA factors are both limiting and required transcriptional regulatory molecules in placental trophoblasts, and that the tissue specificity of the placental lactogen I gene is determined, at least in part, by GATA-2 and/or Gata-3.
Localization of placental lactogen-I in trophoblast giant cells of the mouse placenta.
- T. Faria, L. Ogren, F. Talamantes, D. Linzer, M. Soares
- BiologyBiology of reproduction
- 1 February 1991
The purpose of this investigation was to identify the cellular origin of placental lactogen-I (PL-I) expression in the mouse placenta and to cytologically define the transition from PL-I to PL-II…
The different forms of the prolactin receptor in the rat corpus luteum: developmental expression and hormonal regulation in pregnancy.
Investigation of the corpora lutea of pregnancy in the rat found that the corpus luteum of pregnancy expresses both the short and long forms of the PRL-R with the long form being more abundant, and that both A kinase and tyrosine kinase mediated pathways appear to participate in the up-regulatory mechanism involved in PRl-R mRNA expression.
A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter
- L. Lum, L. Sultzman, R. Kaufman, D. Linzer, B. Wu
- Biology, Computer ScienceMolecular and cellular biology
- 1 December 1990
A novel cDNA clone encoding a 114-kDa polypeptide that binds to the CCAAT element of the hsp70 promoter is isolation and shows no homology to the previously identified human C CAAT transcription factor or rat CCAat/enhancer-binding protein.