Opposing Effects of Adiponectin Receptors 1 and 2 on Energy Metabolism
The adipocyte-derived hormone adiponectin regulates glucose and lipid metabolism and influences the risk for developing obesity, type 2 diabetes, and cardiovascular disease and AdipoR2 is clearly involved in energy metabolism but have opposing effects.
Long-term growth hormone excess induces marked alterations in lipoprotein metabolism in mice.
- F. Frick, M. Bohlooly-y, J. Oscarsson
- Biology, MedicineAmerican Journal of Physiology. Endocrinology and…
- 1 December 2001
Long-term GH excess is associated with marked alterations in lipid and lipoprotein metabolism, indicating decreased production and increased degradation of VLDL and preferential flux of fatty acids to muscle tissues.
Sex difference in hepatic peroxisome proliferator-activated receptor alpha expression: influence of pituitary and gonadal hormones.
Sex hormones regulate the sex difference in hepatic PPARalpha levels, but not via the sexually dimorphic GH secretory pattern, which is not influenced by gender, gonadectomy, hypophysectomy, or GH treatment.
Review article: the emerging role of genetics in precision medicine for patients with non‐alcoholic steatohepatitis
Emerging data indicate that genetic susceptibility increases risks of NAFLD, NASH and NASH‐related cirrhosis.
Activation of Peroxisome Proliferator-activated Receptor α Increases the Expression and Activity of Microsomal Triglyceride Transfer Protein in the Liver*
PPARα activation stimulates hepatic MTP expression via increased transcription of the Mtp gene, indicating that the effect of Wy on apoB-100 secretion is mediated by increased expression of MTP.
The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids
The data suggest that the 3D in vitro spheroids can be used to investigate the mechanisms underlying the association of human genetic variants associated with nonalcoholic fatty liver disease and may also be suitable to discover new treatments against NAFLD.
Liver‐directed overexpression of mitochondrial glycerol‐3‐phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid oxidation
The hypothesis that increased hepatic mtGPAT activity associated with obesity and insulin resistance contributes to increased TAG biosynthesis and inhibition of fatty acid oxidation, responses that would promote hepatic steatosis and dyslipidemia is supported.
Overexpression of mitochondrial GPAT in rat hepatocytes leads to decreased fatty acid oxidation and increased glycerolipid biosynthesis Published, JLR Papers in Press, April 21, 2004. DOI…
- D. Lindén, L. William-Olsson, M. Rhedin, A. Asztély, J. Clapham, S. Schreyer
- BiologyJournal of Lipid Research
- 1 July 2004
The concept that increased hepatic mtGPAT activity associated with obesity positively contributes to lipid disorders by reducing oxidative processes and promoting de novo glycerolipid synthesis is supported.
Growth hormone overexpression in the central nervous system results in hyperphagia-induced obesity associated with insulin resistance and dyslipidemia.
GH overexpression in the CNS results in hyperphagia-induced obesity indicating a dual effect of GH with a central stimulation of appetite and a peripheral lipolytic effect.
The Beneficial Effects of n-3 Polyunsaturated Fatty Acids on Diet Induced Obesity and Impaired Glucose Control Do Not Require Gpr120
Gpr120 deficient animals were found to have similar energy, glucose and lipid metabolism when fed HFD PUFA compared to wild type mice, suggesting GPR120 appears to be dispensable for the improved metabolic profile associated with intake of a diet enriched in n-3 PUFA fatty acids.