Application of 1H NMR‐based metabonomics in the study of metabolic profiling of human hepatocellular carcinoma and liver cirrhosis
Results indicate that serum NMR spectra combined with pattern recognition analysis techniques offer an efficient, convenient way of depicting tumor biochemistry, which may be of great benefit to early diagnosis of human malignant diseases using single blood samples.
Snake Cathelicidin from Bungarus fasciatus Is a Potent Peptide Antibiotics
Potent, broad spectrum, salt-independent antimicrobial activities make cathelicidin-BF an excellent candidate for clinical or agricultural antibiotics and discovery of snake cathe Alicidin with atypical structural and functional characterization offers new insights on the evolution of cathe Licidins.
Antioxidant Peptidomics Reveals Novel Skin Antioxidant System*S
A large amount of antioxidant peptides belonging to 11 different groups with variable structures were isolated from the skin secretions of R. pleuraden, possibly revealing a new skin antioxidant system.
Identification of a Substrate Recognition Site on Ubc9*
- D. Lin, M. Tatham, Bin Yu, Suhkmann Kim, R. Hay, Yuan Chen
- Biology, ChemistryJournal of Biological Chemistry
- 14 June 2002
Human Ubc9 is homologous to ubiquitin-conjugating enzymes. However, instead of conjugating ubiquitin, it conjugates a ubiquitin homologue, small ubiquitin-like modifier 1 (SUMO-1), also known as…
Structural Mechanism of Ring-opening Reaction of Glucose by Human Serum Albumin*
- Yu Wang, Haiyang Yu, Xiaoli Shi, Zhipu Luo, D. Lin, Mingdong Huang
- BiologyJournal of Biological Chemistry
- 16 April 2013
Two protein crystal structures of HSA in complex with either glucose or fructose reveal the presence of linear forms of sugar for both monosaccharides and propose a mechanism for glucose ring opening involving both residues Lys-195 and Lys-199.
Molecular Basis of the Interaction of Saccharomyces cerevisiae Eaf3 Chromo Domain with Methylated H3K36*
- Bingfa Sun, Jing Hong, Jianping Ding
- Chemistry, BiologyJournal of Biological Chemistry
- 26 December 2008
The molecular mechanism of the recognition and binding of the methylated H3K36 by Eaf3 is revealed and new insights are provided into the functional roles of the Eaf2 chromo domain.
Metabonomic profiling of renal cell carcinoma: high-resolution proton nuclear magnetic resonance spectroscopy of human serum with multivariate data analysis.
Unique Structural Characteristics of the Rabbit Prion Protein*
The results suggest that the ordered loop 165–172 and its interaction with helix-3, together with the unique distribution of surface electrostatic potential, significantly contribute to the unique structural characteristics of RaPrPC.
Structure and function of a potent lipopolysaccharide-binding antimicrobial and anti-inflammatory peptide.
A novel potent peptide antibiotic with both antimicrobial and anti-inflammatory activities is identified from the skin secretions of the frog Paa yunnanensis and laid the groundwork for future research and development.
Odorranalectin Is a Small Peptide Lectin with Potential for Drug Delivery and Targeting
These findings identify the smallest lectin so far, and show the application potential of odorranalectin for drug delivery and targeting, and disclosed a new strategy of amphibian anti-infection.