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RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming
N6-methyladenosine (m6A) is a reversible mRNA modification that has been shown to play important roles in various biological processes. However, the roles of m6A modification in macrophages are still
MicroRNA-30d/JAG1 axis modulates pulmonary fibrosis through Notch signaling pathway.
Galectin-3 and β-catenin are associated with a poor prognosis in serous epithelial ovarian cancer
TLDR
Gal-3 may serve as a prognostic factor for SEOC and downregulating Gal-3 expression attenuated the protein expressions of Wnt/β-catenin pathway in ovarian cancer cell lines.
Overexpression of CST4 promotes gastric cancer aggressiveness by activating the ELFN2 signaling pathway.
TLDR
It is shown that cystatin 4 (CST4) is markedly upregulated in gastric cancer cell lines and clinical tissues and it is demonstrated that CST4 enhanced gastric cancers aggressiveness by regulating ELFN2 signaling.
Nicotinamide adenine dinucleotide ( NAD ) may affect DNA methyltransferase 1 through regulation of BRCA 1 in ovarian cancer
Nicotinamide adenine dinucleotide (NAD) is a crucial molecule of energy production and signal transduction processes that have been linked to ovarian cancer development. Notably, emerging evidence
Crosstalk between brca1 and Hormone Receptor Signaling Pathways in Ovarian Cancer Progression
Ovarian cancer is characterized by a high rate of mortality among gynecologic oncology patients [1]. To date, although the exact cause of ovarian cancer are poorly understood, BRCA mutations are the
Crosstalk between brca1 and Hormone Receptor Signaling Pathways in Ovarian Cancer Progression
Ovarian cancer is characterized by a high rate of mortality among gynecologic oncology patients [1]. To date, although the exact cause of ovarian cancer are poorly understood, BRCA mutations are the
Bai-He-Gu-Jin-Tang formula suppresses lung cancer via AKT/GSK3β/β-catenin and induces autophagy via the AMPK/mTORC1/ULK1 signaling pathway
TLDR
It is demonstrated that the AKT/GSK3β/β-catenin signaling pathways were responsible for BHGJT-induced apoptosis in lung cancer cells and represents a potential complementary and alternative treatment for lung cancer.
Overexpression of CST 4 promotes gastric cancer aggressiveness by activating the ELFN 2 signaling pathway
Gastric cancer is one of the most lethal malignancies of gastrointestinal cancer and its prognosis remains dismal because of the paucity of effective therapeutic targets. Here, we show that cystatin