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Cortical inhibitory neurons and schizophrenia
Convergent findings indicate that a deficiency in signalling through the TrkB neurotrophin receptor leads to reduced GABA synthesis in the parvalbumin-containing subpopulation of inhibitory GABA neurons in the dorsolateral prefrontal cortex of individuals with schizophrenia.
Gene Expression Deficits in a Subclass of GABA Neurons in the Prefrontal Cortex of Subjects with Schizophrenia
Testing the expression of mRNAs for PV, calretininin (CR), and glutamic acid decarboxylase (GAD67) in postmortem brain specimens found that in subjects with schizophrenia only 55% of PV mRNA-positive neurons had detectable levels of GAD67 mRNA, while in matched control subjects the same measures of CR mRNA expression were not altered in schizophrenia.
Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia
It is shown that schizophrenia is polygenic and the utility of this resource of gene expression and its genetic regulation for mechanistic interpretations of genetic liability for brain diseases is highlighted.
Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia.
This region- and disease-specific decrease in dendritic spine density on dorsolateral prefrontal cortex layer 3 pyramidal cells is consistent with the hypothesis that the number of cortical and/or thalamic excitatory inputs to these neurons is altered in subjects with schizophrenia.
Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia
Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients
Development of neuroprotective therapies will require elucidation of the molecular mechanisms by which neurons and axons degenerate, according to the role of demyelinated axons in multiple sclerosis.
Local circuit neurons immunoreactive for calretinin, calbindin D‐28k or parvalbumin in monkey prefronatal cortex: Distribution and morphology
- F. Condé, J. Lund, D. Jacobowitz, K. Baimbridge, D. Lewis
- BiologyThe Journal of comparative neurology
- 1 March 1994
This study used immunohistochemical techniques to characterize and compare the morphological features and distribution in macaque monkey prefrontal cortex of local circuit neurons that contain each of the calretinin, calbindin, and parvalbumin proteins.
Catching Up on Schizophrenia Natural History and Neurobiology
Relationship of Brain-Derived Neurotrophic Factor and Its Receptor TrkB to Altered Inhibitory Prefrontal Circuitry in Schizophrenia
Investigating the involvement of signaling mediated by brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase TrkB in producing the altered GABA-related gene expression in schizophrenia found decreased TrkB signaling appears to underlie the dysfunction of inhibitory neurons in the PFC of subjects with schizophrenia.