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Regulation of aflatoxin biosynthesis: effect of glucose on activities of various glycolytic enzymes
The results suggest that glucose may, in part, regulate aflatoxin synthesis via a carbon catabolite repression of NADPH-generating and tricarboxylic acid cycle enzymes. Expand
Cytochromes P450 and species differences in xenobiotic metabolism and activation of carcinogen.
This paper focuses on examples in which species differences in P450s lead to significant alterations in carcinogenic response, and includes a discussion of the current procedures for toxicity screening, with an emphasis on short-term tests. Expand
Studies on a toxic metabolite from the mould Wallemia.
The minimum inhibitory dose of walleminol A in the bioassays is approximately 50 micrograms/ml, which is comparable with a number of mycotoxins such as citrinin and penicillic acid. Expand
COMPACT and molecular structure in toxicity assessment: a prospective evaluation of 30 chemicals currently being tested for rodent carcinogenicity by the NCI/NTP.
The overall prediction for carcinogenicity was positive for 12 of 30 chemicals: nitromethane, chloroprene, D&C Yellow No. 11, molybdenum trioxide, 1-chloro-2-propanol, furfuryl alcohol, gallium arsenide, anthraquinone, emodin, sodium nitrite, cinnamaldehyde, vanadium pentoxide). Expand
Caffeine inhibition of aflatoxin synthesis: probable site of action
It appears likely that caffeine inhibits aflatoxin synthesis by restricting the uptake of carbohydrates which are ultimately used by the mold to synthesize this family of mycotoxins. Expand
Metabolic Activation of Carcinogens and Toxic Chemicals
The computer graphic method of determining the molecular conformations and electronic structures of molecules is a rapid, scientifically-based procedure for evaluation of the potential toxicity, mutagenicity and carcinogenicity of chemicals. Expand
A retrospective evaluation of COMPACT predictions of the outcome of NTP rodent carcinogenicity testing.
The carcinogenic potentials of 40 National Toxicology Program chemicals previously predicted by Computer Optimised Molecular Parametric Analysis for Chemical Toxicity (COMPACT), based on theExpand
A Comparison between COMPACT and Hazardexpert Evaluations for 80 Chemicals Tested by the NTP/NCI Rodent Bioassay
In this study, COMPACT was able to identify correctly most rodent carcinogens, and the Hazardexpert system showed a high concordance with non-carcinogens, in particular. Expand
The Safety Evaluation of Drugs and Chemicals by the Use of Computer Optimised Molecular Parametric Analysis of Chemical Toxicity (COMPACT)
The historical development of the safety evaluation of drugs and chemicals is critically reviewed, and failures of the present approach using experimental animals are examined. The roles of theExpand
Computer modelling and in vitro tests in the safety evaluation of chemicals-Strategic applications.
A new strategy based on the P-450s has resulted in the development of a computer program (COMPACT) and of a programme of enzyme induction studies, as short-term tests to predict the potential toxicity/carcinogenicity of chemicals. Expand