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COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives
TLDR
The interaction between the viral spike protein and angiotensin-converting enzyme 2, which triggers entry of the virus into host cells, is likely to be involved in the cardiovascular manifestations of COVID-19.
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Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice
TLDR
It is shown that TslP expression was increased in the lungs of mice with antigen-induced asthma, whereas TSLP receptor–deficient mice had considerably attenuated disease.
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Human CD4+ T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function
TLDR
It is demonstrated that protein tyrosine kinase 7 (PTK7) is a novel marker for humanCD4+ RTEs and should be useful for monitoring thymic output in both healthy individuals and in patients with genetic or acquired CD4+ T cell immunodeficiencies.
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Cellular Immune Responses in Children and Adults Receiving Inactivated or Live Attenuated Influenza Vaccines
TLDR
The findings identify age, type of vaccine, and prevaccination levels of immune reactivity to influenza A virus as factors significantly associated with the magnitude of cellular immune responses to influenza vaccines.
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Newborn screening for severe combined immunodeficiency and T-cell lymphopenia in California: results of the first 2 years.
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A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40 phox and selective defects in neutrophil NADPH oxidase activity.
TLDR
It is reported the first case of autosomal recessive mutations in NCF4, the gene encoding p40(phox), in a boy who presented with granulomatous colitis, and its absence can be associated with disease.
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Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza
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Global study of primary immunodeficiency diseases (PI)—diagnosis, treatment, and economic impact: an updated report from the Jeffrey Modell Foundation
TLDR
The results strongly indicate the measurable impact of Physician Education and Public Awareness in identifying patients with an underlying PI and a substantial cost savings for diagnosed patients compared to undiagnosed, even if regular IgG is required.
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Influence of the route of allergen administration and genetic background on the murine allergic pulmonary response.
TLDR
In BALB/c mice, induction of maximal airway hyperresponsiveness and airspace eosinophilia required administration of ovalbumin by both the intra peritoneal and the intranasal routes (combination protocol), whereas intraperitoneal immunization alone resulted in maximal ovalbumIn-specific IgE plasma levels.
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NFAT1 enhances HIV-1 gene expression in primary human CD4 T cells.
TLDR
Cyclosporin A is a potent inhibitor of the NFAT family of transcription factors that enhance T cell activation and may be a target for prevention of HIV-1 LTR-directed gene expression in human CD4 T cells.
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