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COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives
- M. Nishiga, Daowen Wang, Yaling Han, D. Lewis, Joseph C. Wu
- Biology, MedicineNature Reviews Cardiology
- 20 July 2020
The interaction between the viral spike protein and angiotensin-converting enzyme 2, which triggers entry of the virus into host cells, is likely to be involved in the cardiovascular manifestations of COVID-19.
Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice
It is shown that TslP expression was increased in the lungs of mice with antigen-induced asthma, whereas TSLP receptor–deficient mice had considerably attenuated disease.
Human CD4+ T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function
It is demonstrated that protein tyrosine kinase 7 (PTK7) is a novel marker for humanCD4+ RTEs and should be useful for monitoring thymic output in both healthy individuals and in patients with genetic or acquired CD4+ T cell immunodeficiencies.
Cellular Immune Responses in Children and Adults Receiving Inactivated or Live Attenuated Influenza Vaccines
The findings identify age, type of vaccine, and prevaccination levels of immune reactivity to influenza A virus as factors significantly associated with the magnitude of cellular immune responses to influenza vaccines.
Newborn screening for severe combined immunodeficiency and T-cell lymphopenia in California: results of the first 2 years.
A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40 phox and selective defects in neutrophil NADPH oxidase activity.
It is reported the first case of autosomal recessive mutations in NCF4, the gene encoding p40(phox), in a boy who presented with granulomatous colitis, and its absence can be associated with disease.
Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza
Global study of primary immunodeficiency diseases (PI)—diagnosis, treatment, and economic impact: an updated report from the Jeffrey Modell Foundation
The results strongly indicate the measurable impact of Physician Education and Public Awareness in identifying patients with an underlying PI and a substantial cost savings for diagnosed patients compared to undiagnosed, even if regular IgG is required.
Influence of the route of allergen administration and genetic background on the murine allergic pulmonary response.
- Y. Zhang, W. Lamm, R. Albert, E. Chi, W. Henderson, D. Lewis
- Biology, MedicineAmerican journal of respiratory and critical care…
- 1 February 1997
In BALB/c mice, induction of maximal airway hyperresponsiveness and airspace eosinophilia required administration of ovalbumin by both the intra peritoneal and the intranasal routes (combination protocol), whereas intraperitoneal immunization alone resulted in maximal ovalbumIn-specific IgE plasma levels.
NFAT1 enhances HIV-1 gene expression in primary human CD4 T cells.
- R. Cron, S. Bartz, A. Clausell, S. Bort, S. Klebanoff, D. Lewis
- BiologyClinical immunology
- 1 March 2000
Cyclosporin A is a potent inhibitor of the NFAT family of transcription factors that enhance T cell activation and may be a target for prevention of HIV-1 LTR-directed gene expression in human CD4 T cells.