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Involvement of an Actomyosin Contractile Ring in Saccharomyces cerevisiae Cytokinesis
In Saccharomyces cerevisiae, the mother cell and bud are connected by a narrow neck. The mechanism by which this neck is closed during cytokinesis has been unclear. Here we report on the role of aExpand
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Septin-Dependent Assembly of a Cell Cycle-Regulatory Module in Saccharomyces cerevisiae
ABSTRACT Saccharomyces cerevisiae septin mutants have pleiotropic defects, which include the formation of abnormally elongated buds. This bud morphology results at least in part from a cell cycleExpand
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Assembly of Scaffold-mediated Complexes Containing Cdc42p, the Exchange Factor Cdc24p, and the Effector Cla4p Required for Cell Cycle-regulated Phosphorylation of Cdc24p*
In budding yeast cells, the cytoskeletal polarization and depolarization events that shape the bud are triggered at specific times during the cell cycle by the cyclin-dependent kinase Cdc28p.Expand
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Scaffold-mediated symmetry breaking by Cdc42p
Cell polarization generally occurs along a single well-defined axis that is frequently determined by environmental cues such as chemoattractant gradients or cell–cell contacts, but polarization canExpand
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Morphogenesis in the yeast cell cycle: regulation by Cdc28 and cyclins
Analysis of cell cycle regulation in the budding yeast Saccharomyces cerevisiae has shown that a central regulatory protein kinase, Cdc28, undergoes changes in activity through the cell cycle byExpand
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Symmetry-Breaking Polarization Driven by a Cdc42p GEF-PAK Complex
BACKGROUND In 1952, Alan Turing suggested that spatial patterns could arise from homogeneous starting conditions by feedback amplification of stochastic fluctuations. One example of suchExpand
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The Morphogenesis Checkpoint in Saccharomyces cerevisiae: Cell Cycle Control of Swe1p Degradation by Hsl1p and Hsl7p
ABSTRACT In Saccharomyces cerevisiae, the Wee1 family kinase Swe1p is normally stable during G1 and S phases but is unstable during G2 and M phases due to ubiquitination and subsequent degradation.Expand
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The septin cortex at the yeast mother-bud neck.
A specialized cortical domain is organized by the septins at the necks of budding yeast cells. Recent findings suggest that this domain serves as a diffusion barrier and also as a local cell-shapeExpand
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Septin ring assembly involves cycles of GTP loading and hydrolysis by Cdc42p
At the beginning of the budding yeast cell cycle, the GTPase Cdc42p promotes the assembly of a ring of septins at the site of future bud emergence. Here, we present an analysis of cdc42 mutants thatExpand
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The spindle assembly and spindle position checkpoints.
  • D. Lew, D. Burke
  • Biology, Medicine
  • Annual review of genetics
  • 28 November 2003
The mitotic spindle segregates chromosomes to opposite ends of the cell in preparation for cell division. Chromosome attachment to the spindle is monitored by the spindle assembly checkpoint, and atExpand
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