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Free radicals and antioxidants in normal physiological functions and human disease.
Gradient selection in inverse heteronuclear correlation spectroscopy
After a brief theoretical description, new gradient‐selected, proton‐detected heteronuclear correlation sequences are introduced. The gs‐HMBC and gs‐Relayed‐HMQC are closely related to the original…
Multinuclear NMR studies on the energy metabolism of glial and neuronal cells.
In this multinuclear NMR study myo-inositol is identified as a glia-specific marker for in vivo NMR studies and a considerable contribution of the anaplerotic pathway in primary neurons from rat is indicated.
Evolution of Regional Changes in Apparent Diffusion Coefficient during Focal Ischemia of Rat Brain: The Relationship of Quantitative Diffusion NMR Imaging to Reduction in Cerebral Blood Flow and…
- M. Hoehn-Berlage, D. Norris, K. Kohno, G. Mies, D. Leibfritz, K. Hossmann
- MedicineJournal of cerebral blood flow and metabolism…
- 1 November 1995
The quantification of ADC in the ischemic territory allows the distinction between a core region with total breakdown of energy metabolism and a corona with normal energy balance but severe tissue acidosis.
Selective increase of brain lactate synthesis in experimental acute liver failure: Results of a [1H‐13C] nuclear magnetic resonance study
Increased brain lactate synthesis and impaired glucose oxidative pathways rather than intracellular glutamine accumulation are the major cause of brain edema in ALF.
On the application of ultra‐fast rare experiments
The ultra‐fast application of the RARE experiment is described in detail, with special emphasis on its multifarious applications with preparation experiments that produce transverse magnetization.…
Energy Metabolism in Astrocytes and Neurons Treated with Manganese: Relation among Cell-Specific Energy Failure, Glucose Metabolism, and Intercellular Trafficking Using Multinuclear NMR-Spectroscopic…
- C. Zwingmann, D. Leibfritz, A. Hazell
- Biology, ChemistryJournal of cerebral blood flow and metabolism…
- 1 June 2003
Changes in astrocytic metabolism may cause a loss of intercellular homeostatic equilibrium, contributing to neuronal dysfunction in manganese neurotoxicity.
Metabolism of Glycine in Primary Astroglial Cells: Synthesis of Creatine, Serine, and Glutathione
- R. Dringen, S. Verleysdonk, B. Hamprecht, W. Willker, D. Leibfritz, A. Brand
- Biology, ChemistryJournal of neurochemistry
- 1 February 1998
Astroglial cells are able to utilize glycine as a precursor for the synthesis of creatine and serine, which proves that at least one cell type of the brain is able to synthesize creatine.
Inversion recovery snapshot FLASH MR imaging.
- A. Haase, D. Matthaei, R. Bartkowski, E. Dühmke, D. Leibfritz
- MedicineJournal of computer assisted tomography
- 1 November 1989
This work describes snapshot FLASH MR using a single 180 degrees pulse prior to the acquisition of a series of FLASH images, which creates continuous dynamic inversion recovery (IR) T1 contrast in successive images.
Metabolic Effects of Dental Resin Components in vitro Detected by NMR Spectroscopy
- J. Engelmann, G. Leyhausen, D. Leibfritz, W. Geurtsen
- Biology, MedicineJournal of dental research
- 1 March 2001
Analysis of the data shows that NMR spectroscopy of cell-material interactions may reveal metabolic effects of organic test substances which are not detectable by standard in vitro assays.