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Acquired chromosome rearrangements in human lymphocytes: effect of aging
SummaryA prospective study of structural rearrangements occurring in normal lymphocytes was carried out. For each of two newborns and four young and two old adults, about 1000 metaphases from 72-hExpand
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Aneuploidy in human lymphocytes: an extensive study of eight individuals of various ages.
Data on aneuploidy from a prospective study on a large number of lymphocyte metaphases (over 1000 in 72-h and 100 in 48-h cultures) per individual from eight healthy donors of various ages areExpand
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CD44 expression patterns in breast and colon tumors: A pcr‐based study of splice variants
CD44 cell‐surface receptor expresses multiple isoforms, some of which are believed to play a role in tumor growth and metastasis. The CD44 gene is composed of 19 exons, of which 9 (exons 6 to 14) areExpand
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DNA methylation and chromosome instability in lymphoblastoid cell lines
In order to gain more insight into the relationships between DNA methylation and genome stability, chromosomal and molecular evolutions of four Epstein-Barr virus–transformed human lymphoblastoidExpand
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Concerted nonsyntenic allelic loss in human colorectal carcinoma.
Familial polyposis coli (FPC) is caused by an autosomal dominant gene on chromosome 5, and it has been proposed that colorectal cancer in the general population arises from loss or inactivation ofExpand
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Hypomethylation of classical satellite DNA and chromosome instability in lymphoblastoid cell lines
To determine possible relationships between DNA hypomethylation and chromosome instability, human lymphoblastoid cell lines from different genetic constitutions were studied with regard to 1)Expand
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Pyrimidine nucleotide metabolism in human colon carcinomas: Comparison of normal tissues, primary tumors and xenografts
The activities of 5 enzymes involved in the pyrimidine metabolism were measured in xenografts of 8 human colon adenocarcinomas and in the corresponding primary tumors and normal tissues. The enzymesExpand
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The rate of chromosome breakage is age dependent in lymphocytes of adult controls
SummaryChromosome breaks and chromatid-type lesions from a prospective study of more than 1000 lymphocyte karyotypes from each of six controls were analysed. These lesions were more frequent in olderExpand
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Preservation of chromosome and DNA characteristics of human colorectal adenocarcinomas after passage in nude mice
Twenty‐seven human colorectal adenocarcinomas were implanted s.c. into nude mice. A comparative study of chromosomes and DNA between fresh tumor (FT) and xenografted tumor cells (XT) could beExpand
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Relationships between UMPK and PGD activities and deletions of chromosome 1p in colorectal cancers.
A deletion involving a large segment of the short arm of chromosome 1(1p-) occurs in about 50% of colorectal cancers. It was previously noticed that, in these tumors, many deletions affect genesExpand
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