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CD44 expression patterns in breast and colon tumors: A pcr‐based study of splice variants
TLDR
The data indicate that expression of metastatic variants is common in human breast and colon tumors and can occur early during cancer progression, as testified by their presence in a benign breast tumor. Expand
Acquired chromosome rearrangements in human lymphocytes: effect of aging
TLDR
The first type of rearrangement, which occurs in utero, may correspond to immunoglobulin and related gene rearrangements and the second type, which seems to accumulate progressively and may reflect exposure to mutagens, is import to discriminate when studying the effect of low doses ofmutagens. Expand
Concerted nonsyntenic allelic loss in human colorectal carcinoma.
TLDR
It appears that FPC is a true dominant for adenomatosis but not a common recessive gene for colon cancer; and simple Mendelian models involving loss of alleles at a single locus may be inappropriate for understanding common human solid tumors. Expand
Aneuploidy in human lymphocytes: an extensive study of eight individuals of various ages.
TLDR
Although the rate of aneuploidy limited to autosomes was similar in newborns and in adults, the distributions of the missing autosomes were different and a significant inverse correlation with autosome lengths was observed. Expand
DNA methylation and chromosome instability in lymphoblastoid cell lines
TLDR
Analysis of chromosomal and molecular evolutions of four Epstein-Barr virus–transformed human lymphoblastoid cell lines followed in culture suggests that the influence of DNA demethylation on chromosome stability is modulated by a sequence-specific chromatin structure. Expand
Hypomethylation of classical satellite DNA and chromosome instability in lymphoblastoid cell lines
TLDR
In these lymphoblastoid cell lines, alterations characterized by uncoiling and rearrangements of heterochromatic segments from chromosomes 1 and 16 seem to correlate with the hypomethylation of their repetitive DNAs. Expand
Preservation of chromosome and DNA characteristics of human colorectal adenocarcinomas after passage in nude mice
TLDR
Comparison between corresponding FT and XT karyotypes showed great similarities, however, the tendency toward polyploidization, which exists in FTs, appeared to be more pronounced in XTs, which was correlated with loss of heterozygosity for these chromosomes. Expand
Relationships between UMPK and PGD activities and deletions of chromosome 1p in colorectal cancers.
TLDR
The fact that no gene dosage effect exists, although the tendency for del(1p) coexists with the relative decrease of U MPK activity in cancerous by comparison to non-cancerous cells, suggests that either mutation or disregulation of UMPK gene occurred early. Expand
Pyrimidine nucleotide metabolism in human colon carcinomas: Comparison of normal tissues, primary tumors and xenografts
TLDR
The results raise questions concerning the representativeness of xenografts with reference to primary tumors and suggest that care should be taken in the application of this model. Expand
Activity of thymidylate synthetase, thymidine kinase and galactokinase in primary and xenografted human colorectal cancers in relation to their chromosomal patterns
TLDR
Data suggest that serial studies on grafted colorectal cancers give a better representation of metabolic disturbances than studies on fresh tumor samples, usually contaminated by non‐cancerous cells. Expand
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