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Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice.
- C. Zuany-Amorim, S. Haile, +4 authors M. Pretolani
- The Journal of clinical investigation
- 1 June 1995
This report examines the effect of recombinant murine (rm) IL-10 on antigen-induced cellular recruitment into the airways of sensitized Balb/c mice. The intranasal instillation of 10 micrograms… Expand
Leukocyte Elastase Negatively Regulates Stromal Cell-derived Factor-1 (SDF-1)/CXCR4 Binding and Functions by Amino-terminal Processing of SDF-1 and CXCR4*
- A. Valenzuela-Fernández, T. Planchenault, +9 authors F. Arenzana-Seisdedos
- Medicine, Biology
- The Journal of Biological Chemistry
- 3 May 2002
Activation of CXCR4 by the CXC chemokine stromal cell-derived factor-1 (SDF-1) requires interaction of the amino-terminal domains of both molecules. We report that proteinases released from either… Expand
Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells.
- Sophie Dulon, D. Leduc, +6 authors M. Chignard
- Biology, Medicine
- American journal of respiratory cell and…
- 1 May 2005
Pseudomonas aeruginosa, a major lung pathogen in cystic fibrosis (CF) patients, secretes an elastolytic metalloproteinase (EPa) contributing to bacterial pathogenicity. Proteinase-activated receptor… Expand
Systemic administration of endotoxin induces bronchopulmonary hyperreactivity dissociated from TNF-alpha formation and neutrophil sequestration into the murine lungs.
Bronchopulmonary hyperreactivity (BHR), an increased responsiveness to nonspecific bronchoconstrictor agents, is a well-known characteristic of bronchial asthma. It has been recently suggested that… Expand
Effect of antigen provocation of IL-5 transgenic mice on eosinophil mobilization and bronchial hyperresponsiveness.
- J. Lefort, C. Bachelet, D. Leduc, B. Vargaftig
- The Journal of allergy and clinical immunology
- 1 March 1996
We investigated whether allergen-induced eosinophil recruitment into mouse airways modifies the in vivo bronchopulmonary responses to standard agonists, and adaptation of a technique described for… Expand
Anthrax Lethal Toxin Impairs IL-8 Expression in Epithelial Cells through Inhibition of Histone H3 Modification
Lethal toxin (LT) is a critical virulence factor of Bacillus anthracis, the etiological agent of anthrax, whose pulmonary form is fatal in the absence of treatment. Inflammatory response is a key… Expand
The Pseudomonas aeruginosa LasB Metalloproteinase Regulates the Human Urokinase-Type Plasminogen Activator Receptor through Domain-Specific Endoproteolysis
ABSTRACT Pseudomonas aeruginosa is an opportunistic pathogen in human lungs, where its secretable LasB metalloproteinase can be a virulence factor. The urokinase-type plasminogen activator receptor… Expand
Plasmin cleaves the juxtamembrane domain and releases truncated species of the urokinase receptor (CD87) from human bronchial epithelial cells
- N. Beaufort, D. Leduc, J. Rousselle, A. Namane, M. Chignard, D. Pidard
- Biology, Medicine
- FEBS letters
- 10 September 2004
The three‐domain (D1D2D3) urokinase receptor (CD87) is highly susceptible to cleavage within the D1–D2 linker sequence, but also within the juxtamembrane region by yet poorly characterized… Expand
Proteolytic Regulation of the Urokinase Receptor/CD87 on Monocytic Cells by Neutrophil Elastase and Cathepsin G 1
The urokinase receptor (CD87) participates to the pericellular proteolytic potential of migrating cells and to the recruitment of leukocytes during inflammation. It consists of three structurally… Expand
Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity.
- Erwan Pernet, L. Guillemot, +10 authors L. Touqui
- Biology, Medicine
- Nature communications
- 7 October 2014
Young cystic fibrosis (CF) patients' airways are mainly colonized by Staphylococcus aureus, while Pseudomonas aeruginosa predominates in adults. However, the mechanisms behind this infection switch… Expand