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- Publications
- Influence
Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin.
- D. Meruelo, G. Lavie, D. Lavie
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 July 1988
Two aromatic polycyclic diones hypericin and pseudohypericin have potent antiretroviral activity; these substances occur in plants of the Hypericum family. Both compounds are highly effective in… Expand
A chemotaxonomic study of Withania somnifera (L.) dun.
- A. Abraham, I. Kirson, E. Glotter, D. Lavie
- Biology
- 1 June 1968
Abstract Three chemical types of Wittania somnifera (L.) Dun., Solanaceae, each containing different steroidal lactones of the withanolide type, have been found to occur in Israel; they have been… Expand
Constitutents of Withania somnifera Dun. Part XII. The withanolides of an indian chemotype
- I. Kirson, E. Glotter, D. Lavie, A. Abraham
- Chemistry
- 1971
Eight new steroidal lactones of the withanolide series have been isolated from the leaves of Withania somnifera(Solanaceae) growing in North-Western India. This population of W. somnifera differs… Expand
The chemical and biological properties of hypericin—a compound with a broad spectrum of biological activities
- G. Lavie, Y. Mazur, D. Lavie, D. Meruelo
- Chemistry, Medicine
- Medicinal research reviews
- 1 March 1995
Constituents of Withania somnifera Dun. III. The Side Chain of Withaferin A*,1
- D. Lavie, E. Glotter, Y. Shvo
- Chemistry
- 1 June 1965
Momelotinib versus best available therapy in patients with myelofibrosis previously treated with ruxolitinib (SIMPLIFY 2): a randomised, open-label, phase 3 trial.
- C. Harrison, A. Vannucchi, +10 authors S. Verstovsek
- Medicine
- The Lancet. Haematology
- 2018
BACKGROUND
The Janus kinase (JAK) inhibitor ruxolitinib is the only approved therapy for patients with symptomatic myelofibrosis. After ruxolitinib failure, however, there are few therapeutic… Expand
Constituents of Withania Somnifera Dun. Part X The Structure of Withanolide D
- D. Lavie, I. Kirson, E. Glotter
- Chemistry
- 1968
Withanolide D, the major component of the leaves of Withania somnifera chemotype II, is a steroidal lactone of the withanolide type, isomeric with withaferin A. It has been identified as 5,… Expand
Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin.
- G. Lavie, F. Valentine, +5 authors D. Meruelo
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 August 1989
Administration of the aromatic polycyclic dione compounds hypericin or pseudohypericin to experimental animals provides protection from disease induced by retroviruses that give rise to acute, as… Expand
Inactivation of the human immunodeficiency virus by hypericin: evidence for photochemical alterations of p24 and a block in uncoating.
- S. Degar, A. Prince, +7 authors D. Meruelo
- Biology, Medicine
- AIDS research and human retroviruses
- 1 November 1992
Following attachment and entry of human immunodeficiency virus (HIV) into a host cell, the HIV genomic RNA is reverse transcribed to cDNA. This step may be inhibited by hypericin, a compound that… Expand
Antitumor activity of withaferin A (NSC-101088).
- B. Shohat, S. Gitter, A. Abraham, D. Lavie
- Chemistry, Medicine
- Cancer chemotherapy reports
- 1 September 1967