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Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin.
Two aromatic polycyclic diones hypericin and pseudohypericin have potent antiretroviral activity; these substances occur in plants of the Hypericum family. Both compounds are highly effective inExpand
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A chemotaxonomic study of Withania somnifera (L.) dun.
Abstract Three chemical types of Wittania somnifera (L.) Dun., Solanaceae, each containing different steroidal lactones of the withanolide type, have been found to occur in Israel; they have beenExpand
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Constitutents of Withania somnifera Dun. Part XII. The withanolides of an indian chemotype
Eight new steroidal lactones of the withanolide series have been isolated from the leaves of Withania somnifera(Solanaceae) growing in North-Western India. This population of W. somnifera differsExpand
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Momelotinib versus best available therapy in patients with myelofibrosis previously treated with ruxolitinib (SIMPLIFY 2): a randomised, open-label, phase 3 trial.
BACKGROUND The Janus kinase (JAK) inhibitor ruxolitinib is the only approved therapy for patients with symptomatic myelofibrosis. After ruxolitinib failure, however, there are few therapeuticExpand
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Constituents of Withania Somnifera Dun. Part X The Structure of Withanolide D
Withanolide D, the major component of the leaves of Withania somnifera chemotype II, is a steroidal lactone of the withanolide type, isomeric with withaferin A. It has been identified as 5,Expand
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Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin.
Administration of the aromatic polycyclic dione compounds hypericin or pseudohypericin to experimental animals provides protection from disease induced by retroviruses that give rise to acute, asExpand
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Inactivation of the human immunodeficiency virus by hypericin: evidence for photochemical alterations of p24 and a block in uncoating.
Following attachment and entry of human immunodeficiency virus (HIV) into a host cell, the HIV genomic RNA is reverse transcribed to cDNA. This step may be inhibited by hypericin, a compound thatExpand
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Antitumor activity of withaferin A (NSC-101088).
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