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The transcriptional program in the response of human fibroblasts to serum.
The temporal program of gene expression during a model physiological response of human cells, the response of fibroblasts to serum, was explored with a complementary DNA microarray representing aboutExpand
Systematic variation in gene expression patterns in human cancer cell lines
TLDR
Using cDNA microarrays to explore the variation in expression of approximately 8,000 unique genes among the 60 cell lines used in the National Cancer Institute's screen for anti-cancer drugs provided a novel molecular characterization of this important group of human cell lines and their relationships to tumours in vivo. Expand
Distinctive gene expression patterns in human mammary epithelial cells and breast cancers.
TLDR
The results support the feasibility and usefulness of this systematic approach to studying variation in gene expression patterns in human cancers as a means to dissect and classify solid tumors. Expand
Yeast microarrays for genome wide parallel genetic and gene expression analysis.
TLDR
High-density DNA microarrays of yeast ORFs can monitor hybridization to ORFs for applications such as quantitative differential gene expression analysis and screening for sequence polymorphisms at the whole genome level. Expand
Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar–coding strategy
TLDR
A pilot study with 11 known yeastgenes suggests that the method can be extended to include all of the ORFs in the yeast genome, allowing whole genome analysis with a single selective growth condition and a single hybridization. Expand
A radiation hybrid map of the zebrafish genome
TLDR
A radiation hybrid (RH) map of the zebrafish genome is created, based on somatic cell hybrid lines produced by fusion of lethally irradiated cells of the species of interest with a rodent cell line to facilitate the mapping of candidate genes and to increase the density of markers available for positional cloning. Expand
Functional Analysis of the Genes of Yeast Chromosome V by Genetic Footprinting
TLDR
Genetic footprinting was used to assess the phenotypic effects of Ty1 transposon insertions in 268 predicted genes of chromosome V of Saccharomyces cerevisiae, and new mutant phenotypes were identified. Expand
A genetic linkage map for zebrafish: comparative analysis and localization of genes and expressed sequences.
TLDR
This comparative analysis identified pairs of zebrafish genes that appear to be orthologous to single mammalian genes, suggesting that these genes arose in a genome duplication that occurred in the teleost lineage after the divergence of fish and mammal ancestors. Expand
Genome-wide mapping with biallelic markers in Arabidopsis thaliana
TLDR
The construction of a biallelic genetic map in A. thaliana with a resolution of 3.5 cM is reported and its use in mapping Eds16, a gene involved in the defence response to the fungal pathogen Erysiphe orontii is mapped. Expand
Allelic diversification at the class II DQB locus of the mammalian major histocompatibility complex.
TLDR
The use of oligonucleotide primers to amplify, by the polymerase chain reaction, and sequence the polymorphic second exon of the DQB locus from 11 species, indicates that allelic diversification has occurred subsequent to the divergence of hominoids and some haplotype combinations of DQA and DQB alleles are common to several hominoid species and may have been maintained for at least 5 million years. Expand
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