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Quantitative 1H NMR: development and potential of a method for natural products analysis.
Based on a brief revision of what constitutes state-of-the-art "quantitative experimental conditions" for (1)H quantitative NMR (qHNMR), this comprehensive review contains almost 200 references andExpand
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Discovery and characterization of the tuberculosis drug lead ecumicin.
The new tuberculosis (TB) lead ecumicin (1), a cyclic tridecapeptide, was isolated from Nonomuraea sp. MJM5123, following a high-throughput campaign for anti-TB activity. The large molecular weightExpand
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Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis.
An EtOH extract of the polypore mushroom Fomitopsis officinalis afforded two new naturally occurring chlorinated coumarins, which were identified as the previously synthesized compoundsExpand
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Stereochemical analysis of leubethanol, an anti-TB-active serrulatane, from Leucophyllum frutescens.
Bioactivity-guided fractionation of the methanolic root bark extract of Leucophyllum frutescens led to the identification of leubethanol (1), a new serrulatane-type diterpene with activity againstExpand
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In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent.
Cimicifuga racemosa (L.) Nutt. (syn. Actaea racemosa L., black cohosh) is used to relieve menopausal hot flashes, although clinical studies have provided conflicting data, and the activeExpand
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Natural Deep Eutectic Solvents: Properties, Applications, and Perspectives.
As functional liquid media, natural deep eutectic solvent (NADES) species can dissolve natural or synthetic chemicals of low water solubility. Moreover, the special properties of NADES, such asExpand
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Metabolite Profiling and Classification of DNA-Authenticated Licorice Botanicals.
Raw licorice roots represent heterogeneous materials obtained from mainly three Glycyrrhiza species. G. glabra, G. uralensis, and G. inflata exhibit marked metabolite differences in terms ofExpand
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Quantitative 1H NMR. Development and potential of an analytical method: an update.
This review continues a previous literature overview on quantitative (1)H NMR methodology and its applications in the analysis of natural products. Expand
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Importance of Purity Evaluation and the Potential of Quantitative 1H NMR as a Purity Assay
In any biomedical and chemical context, a truthful description of chemical constitution requires coverage of both structure and purity. This qualification affects all drug molecules, regardless ofExpand
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In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin.
UNLABELLED The lack of a safe and reliable alternative to hormone therapy (HT) for treating menopausal symptoms underscores the need for alternative therapies. OBJECTIVE The purpose of this studyExpand
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