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Tumor Necrosis Factor-α Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2)*
Angiotensin-converting enzyme-2 (ACE2) is a critical regulator of heart function and a cellular receptor for the causative agent of severe-acute respiratory syndrome (SARS), SARS-CoV (coronavirus).Expand
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Substrate‐induced regulation of the human colonic monocarboxylate transporter, MCT1
Butyrate is the principal source of energy for colonic epithelial cells, and has profound effects on their proliferation, differentiation and apoptosis. Transport of butyrate across the colonocyteExpand
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The Role of HOXB9 and miR-196a in Head and Neck Squamous Cell Carcinoma
Background Previous studies have demonstrated that a number of HOX genes, a family of transcription factors with key roles in early development, are up-regulated in head and neck squamous cellExpand
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Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress.
ACE2 (angiotensin-converting enzyme 2) counterbalances the actions of ACE (angiotensin-converting enzyme) by metabolizing its catalytic product, the vasoactive and fibrogenic peptide AngIIExpand
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Angiotensin-converting enzyme 2 and new insights into the renin–angiotensin system
Abstract Components of the renin–angiotensin system are well established targets for pharmacological intervention in a variety of disorders. Many such therapies abrogate the effects of theExpand
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MicroRNA‐124 suppresses oral squamous cell carcinoma motility by targeting ITGB1
Alterations in the levels of molecules which interact with the extracellular matrix, such as integrins, are associated with invasion of oral squamous cell carcinomas (OSCC). The molecular mechanismsExpand
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Calmodulin interacts with angiotensin‐converting enzyme‐2 (ACE2) and inhibits shedding of its ectodomain
Angiotensin‐converting enzyme‐2 (ACE2) is a regulatory protein of the renin–angiotensin system (RAS) and a receptor for the causative agent of severe‐acute respiratory syndrome (SARS), theExpand
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A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts
Senescent cancer-associated fibroblasts (CAF) develop a senescence-associated secretory phenotype (SASP) that is believed to contribute to cancer progression. The mechanisms underlying SASPExpand
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Endothelin‐1 stimulates motility of head and neck squamous carcinoma cells by promoting stromal–epithelial interactions
The invasion and migration of cancer cells is increasingly recognised to be influenced by factors derived from adjacent tumour‐associated stroma. The contextual signals regulating stromal–tumourExpand
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Not just angiotensinases: new roles for the angiotensin-converting enzymes
The renin-angiotensin system (RAS) is a critical regulator of blood pressure and fluid homeostasis. Angiotensin II, the primary bioactive peptide of the RAS, is generated from angiotensin I byExpand
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