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Antinociceptive activity of intrathecally administered cannabinoids alone, and in combination with morphine, in mice.
The antinociceptive effects of various cannabinoids, alone and in combination with opiates, were evaluated in antinociceptive tests in mice. The cannabinoids tested produce marked antinociceptiveExpand
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Alpha toxin from Clostridium perfringens induces proinflammatory changes in endothelial cells.
Alpha toxin from Clostridium perfringens type A, a phospholipase C, has been implicated in many of the localized and systemic features of gas gangrene. We demonstrated that human endothelial cellsExpand
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Measuring the competence of residents as teachers
Medical residents, frontline clinical educators, must be competent teachers. Typically, resident teaching competence is not assessed through any other means than gleaning learner’s comments. WeExpand
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Modulation of opioids via protection of anandamide degradation by fatty acid amide hydrolase.
Lack of involvement of the opioid system with the endocannabinoid, arachidonylethanolamide (anandamide) was possibly due to hydrolysis by fatty acid amide hydrolase (FAAH). Cyclohexylcarbamic acidExpand
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The regulation of platelet-activating factor production in endothelial cells. The role of calcium and protein kinase C.
Endothelial cells (EC) synthesize platelet-activating factor (PAF) when stimulated with agonists that bind to cell-surface receptors. We examined events that link receptor binding to synthesis of PAFExpand
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Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists.
Opioid receptor selective antagonists are important pharmacological probes in opioid receptor structural characterization and opioid agonist functional study. Thus far, a nonpeptidyl, highlyExpand
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Calcium modulation of morphine analgesia: role of calcium channels and intracellular pool calcium.
Calcium (Ca++) administered into the i.c.v. space of mice has been reported to block opioid-induced antinociception dose dependently. These studies were conducted to test the hypothesis that Ca++Expand
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The Role of Several Kinases in Mice Tolerant to Δ9-Tetrahydrocannabinol
It has been suggested that the cannabinoid receptor type 1 (CB1), a G protein-coupled receptor, is internalized after agonist binding and activation of the second messenger pathways. It is proposedExpand
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Decreased basal endogenous opioid levels in diabetic rodents: effects on morphine and delta-9-tetrahydrocannabinoid-induced antinociception.
We have previously demonstrated synergy between morphine and Delta(9)-tetrahydrocannabinol (Delta(9)-THC) in the expression of antinociception in acute pain models and in arthritic models of chronicExpand
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Sensitization of enteric neurons to morphine by HIV‐1 Tat protein
Gastrointestinal (GI) dysfunction is a major cause of morbidity in acquired immunodeficiency syndrome (AIDS). HIV‐1‐induced neuropathogenesis is significantly enhanced by opiate abuse, whichExpand
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