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Magnesium ion catalyzed P-N bond hydrolysis in imidazolide activated nucleotides. Relevance to template-directed synthesis of polynucleotides
Magnesium, an ion necessary in enzymatic as well as in nonenzymatic template-directed polynucleotide-synthesizing reactions, has been found to catalyze the hydroxide ion attack on the P-N bond ofExpand
Magnesium ion catalyzed P-N bond hydrolysis in imidazolide-activated nucleotides. Relevance to template-directed synthesis of polynucleotides.
Magnesium, an ion necessary in enzymatic as well as in nonenzymatic template-directed polynucleotide-synthesizing reactions, has been found to catalyze the hydroxide ion attack on the P-N bond ofExpand
Magnesium Ion Catalyzed P-N Bond Hydrolysis in Imidazolide-Activated Nucleotides. Relevance to Template-Directed Synthesis of Polynucleotides.
A detailed investigation of the hydrolysis of (Ia) in the pH range 6-12.4 at 37 °C is presented.