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A Review of the Microcirculation of Adipose Tissue: Anatomic, Metabolic, and Angiogenic Perspectives
TLDR
An in‐depth analysis of the development of adipose tissue microvasculature indicates that angiogenesis often precedes adipogenesis, and the recent discovery of sites of nuclear regulation of adipocyte differentiation is an indication of the progress that is being made in the further understanding of molecular and cellular events that affect adipOSE tissue growth and, ultimately, adipose tissues microcirculation. Expand
Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization.
TLDR
The remarkable preclinical safety and metabolic stability profiles of tiplaxtinin led to advancing the compound to clinical trials and in vivo oral efficacy in two different models of acute arterial thrombosis. Expand
Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascade
TLDR
PAI-1 inhibitors augment the activity of tPA and plasmin in hippocampus, significantly lower plasma and brain Aβ levels, restore long-term potentiation deficits in hippocampal slices from transgenic Aβ-producing mice, and reverse cognitive deficits in these mice. Expand
Distribution of angiotensin II receptors in rat and human adipocytes.
TLDR
Data indicate site-specific differences in AII receptor number in fat cell membranes from rats and the existence of human adipocyte AII receptors, suggesting that the adipocyte is significant for the peripheral metabolism of components of the renin-angiotensin system. Expand
Rotigaptide (ZP123) Prevents Spontaneous Ventricular Arrhythmias and Reduces Infarct Size During Myocardial Ischemia/Reperfusion Injury in Open-Chest Dogs
TLDR
It is demonstrated that rotigaptide is a potent antiarrhythmic compound with cardioprotective effects and desirable safety in dogs subjected to a 60-min coronary artery occlusion and 4 h of reperfusion injury. Expand
Effect of Experimental Obesity and Subsequent Weight Reduction upon Circulating Atrial Natriuretic Peptide
TLDR
It is suggested that the diuresis and natriuresis accompanying weight reduction may be facilitated by atrial natriuretic peptide, which was elevated in part due to a persistent left ventricular hypertrophy following the transition from the obese to lean condition. Expand
Identification of estrogen receptor beta RNA in human breast and abdominal subcutaneous adipose tissue.
TLDR
The initial observation of the novel estrogen receptor, ER beta, in human subcutaneous adipose tissue indicates that this receptor subtype may have a role in ER-mediated responses in human adipose tissues. Expand
Mapping of a Conformational Epitope on Plasminogen Activator Inhibitor-1 by Random Mutagenesis
TLDR
Results suggest that this intermediate form of PAI-1 has a partial insertion of the reactive center loop into β-sheet A, and together, these data have significant implications for the general serpin mechanism of proteinase inhibition. Expand
Lactate release from isolated rat adipocytes: influence of cell size, glucose concentration, insulin and epinephrine.
TLDR
Adipose tissue may be a major site of lactate production, especially in states of altered glucose metabolism (i.e., hyperglycemia) and obesity, and lactate is a major metabolite of glucose in adipocytes, particularly in the large fat cells. Expand
Development of a human adipocyte synthetic polymer scaffold.
TLDR
Fibronectin-coating resulted in the highest efficiency of sodding, with differentiation of preadipocytes to adipocytes as assessed by scanning electron -microscopy and conventional Oil Red O staining, which may be used for improving soft-tissue augmentation and serving as a delivery system for growth factors important in wound healing. Expand
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