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Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain.
(+/-)-3,4-Methylenedioxymethylamphetamine (MDMA) was administered s.c. to rats (10, 20 or 40 mg/kg b. wt.) and guinea pigs (20 mg/kg) twice a day for 4 days, 2 weeks before decapitation.Expand
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α-Methyl-p-tyrosine pretreatment partially prevents methamphetamine-induced endogenous neurotoxin formation
Depletion of brain dopamine (DA) by pretreatment with the tyrosine hydroxylase inhibitor alpha-methyl-p-tyrosine (AMT) has been shown to prevent the long-term neurotoxic effects of methamphetamineExpand
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5,6-dihydroxytryptamine, a serotonergic neutotoxin, is formed endogenously in the rat brain
Methamphetamine (MA) in high doses produces long-term toxic effects on the serotonergic system in the rat brain, including depletions of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid andExpand
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Neurotoxicity in Dopamine and 5‐Hydroxytryptamine Terminal Fields: A Regional Analysis in Nigrostriatal and Mesolimbic Projections
In summary, we have shown that MA is toxic to both 5-HT and DA cells and we have proposed a mechanism that would account for this response, namely, the conversion of the transmitters to neurotoxins.Expand
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Endogenously produced 5,6-dihydroxytryptamine may mediate the neurotoxic effects of para-chloroamphetamine
Para-chloroamphetamine (PCA) has been used to deplete brain serotonin (5-HT) in numerous studies of serotonergic involvement in various behaviors and physiological functions. PCA is believed to causeExpand
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Variability among brain regions in the specificity of 6-hydroxydopamine (6-OHDA)-induced lesions
6-Hydroxydopamine (6-OHDA; 200 μg, 150 μg or 110 μg) or vehicle was infused stereotaxically into the lateral ventricles of rats, usually following pretreatment with desmethylimipramine (DMI). VariousExpand
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alpha-Methyltyrosine blocks methylamphetamine-induced degeneration in the rat somatosensory cortex.
Neurochemical and histological studies suggest that methylamphetamine (MA) administered continuously or in high doses is toxic to dopaminergic and serotonergic nerve terminals. Degeneration of theExpand
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