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The transcription factor FOXL2 mobilizes estrogen signaling to maintain the identity of ovarian granulosa cells
TLDR
It is found that FOXL2 is required for normal gene regulation by steroid receptors, and it is shown that estrogen receptor beta (ESR2) is the main vector of estradiol signaling in these cells. Expand
Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylase.
TLDR
The body of evidence presented here supports the idea that FOXL2 plays a key role in granulosa cell homeostasis, the failure of which is central to ovarian ageing and tumorigenesis. Expand
FOXL2, GATA4, and SMAD3 Co-Operatively Modulate Gene Expression, Cell Viability and Apoptosis in Ovarian Granulosa Cell Tumor Cells
TLDR
The effects of GATA4 and SMAD3 on both cell viability and apoptosis are distinct from those of wild type FOXL2; a perturbation of this balance due to the oncogenicFOXL2 mutation is likely to contribute to GCT pathogenesis. Expand
Adult ovarian granulosa cell tumor transcriptomics: prevalence of FOXL2 target genes misregulation gives insights into the pathogenic mechanism of the p.Cys134Trp somatic mutation
TLDR
It is found that the OGCT samples analyzed herein exhibit several hallmarks of cancer, including increased expression of genes linked to cell proliferation, but decreased expression of those conferring sensitivity to cell death. Expand
Centimorgan-Range One-Step Mapping of Fertility Traits Using Interspecific Recombinant Congenic Mice
TLDR
53 interspecific recombinant congenic mouse strains bearing 1–2% SEG/Pas (Mus spretus) genomic fragments disseminated in a C57Bl/6J (Mus domesticus) background were used to systematically analyze male fertility parameters and demonstrated the possibility in one-step fine mapping for several fertility traits. Expand
Functional Exploration of the Adult Ovarian Granulosa Cell Tumor-Associated Somatic FOXL2 Mutation p.Cys134Trp (c.402C>G)
TLDR
This is the first study demonstrating that the p.Cys134Trp mutant does not have a strong impact on FOXL2 localization, solubility, and transactivation abilities on a panel of proven target promoters, behaving neither as a dominant-negative nor as a loss-of-function mutation. Expand
Anti-Müllerian hormone: a new actor of sexual dimorphism in pituitary gonadotrope activity before puberty
TLDR
Overall, this study uncovers a new role for AMH in regulating gonadotrope function and suggests that AMH participates in the postnatal elevation of FSH secretion in females. Expand
Interspecific resources: a major tool for quantitative trait locus cloning and speciation research
TLDR
It is argued that interspecific resources may constitute a major genetic tool for positional cloning and for understanding some bases of speciation mechanisms. Expand
Fidgetin-Like1 Is a Strong Candidate for a Dynamic Impairment of Male Meiosis Leading to Reduced Testis Weight in Mice
TLDR
Fidgetin-like 1 (Fignl1) is identified as the gene underlying the phenotype of low testis weight phenotype and is a new potential candidate for human infertilities caused by teratozoospermia and blockades of spermatogenesis. Expand
Frataxin inactivation leads to steroid deficiency in flies and human ovarian cells.
TLDR
The involvement of frataxin in steroid synthesis appears to be a conserved function of the protein from flies to human and the data suggest that steroidogenesis could be affected in FA patients. Expand
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