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Cyclooxygenase-2–Dependent and Thromboxane-Dependent Vascular and Bronchial Responses are Regulated via p38 Mitogen-Activated Protein Kinase in Control and Endotoxin-Primed Rat Lungs
It is concluded that both immunolocalization of p38 activity and pharmacologic interventions support a strong role of the p38 MAPK pathway in establishing an active cyclooxygenase-2/thromboxane synthase axis in vascular and bronchial SMC, with up-regulation of this signaling cascade occurring in LPS priming and being responsible for enhanced pulmonary artery pressor response, edema formation, and Bronchoconstriction. Expand