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Cyclooxygenase-2–Dependent and Thromboxane-Dependent Vascular and Bronchial Responses are Regulated via p38 Mitogen-Activated Protein Kinase in Control and Endotoxin-Primed Rat Lungs
- M. Ermert, D. Kuttner, Nils Eisenhardt, C. Dierkes, W. Seeger, L. Ermert
- Biology, Medicine
- Laboratory Investigation
- 1 March 2003
It is concluded that both immunolocalization of p38 activity and pharmacologic interventions support a strong role of the p38 MAPK pathway in establishing an active cyclooxygenase-2/thromboxane synthase axis in vascular and bronchial SMC, with up-regulation of this signaling cascade occurring in LPS priming and being responsible for enhanced pulmonary artery pressor response, edema formation, and Bronchoconstriction. Expand
Clinical challenges and images in GI. Segmental ischemic colitis owing to vascular malformation of the inferior mesenteric artery.