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Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation.
It is shown that during IRF8-dependent monocyte differentiation, IRf8 binding occurs at both promoter-proximal and promotor-distal regions together with the transcription factor PU and is associated with gene induction. Expand
Shared and Distinct Functions of the Transcription Factors IRF4 and IRF8 in Myeloid Cell Development
It is shown that IRF4 has activities similar to IRF8 in regulating myeloid cell development, and it is demonstrated that Irf8 -/- Irf4 -/- mice exhibit a more severe chronic myeloids leukemia (CML)-like disease than IrF8 -/+ mice, involving a disproportionate expansion of granulocytes at the expense of monocytes/macrophages. Expand
IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils.
Irf8(-/-) haematopoietic progenitors not only bestows monocyte and DC differentiation potential upon mononuclear phagocytes but also restrains these progenitor from differentiating into neutrophils. Expand
α9 Integrin and Its Ligands Constitute Critical Joint Microenvironments for Development of Autoimmune Arthritis1
It is found that not only osteopontin but also tenascin-C and their common receptor, α9Integrin, are expressed at arthritic joints and α9 integrin is identified as a critical intrinsic regulator that controls the development of autoimmune arthritis. Expand
α9β1 Integrin-Mediated Signaling Serves as an Intrinsic Regulator of Pathogenic Th17 Cell Generation
The interaction between matricellular proteins such as tenascin-C (TN-C) and osteopontin (OPN) and integrins has been implicated in the pathology of rheumatoid arthritis in which Th17 cells areExpand
Regulation of myelopoiesis by the transcription factor IRF8
An overview of recent advances in the understanding of the role of IRF8 in myelopoiesis and related diseases is provided. Expand
Functions and development of red pulp macrophages
Red pulp macrophages are capable of inducing differentiation of regulatory T cells via expression of transforming growth factor‐β and secrete a large amount of type I interferons during parasitic infections. Expand
CSF-1–Dependent Red Pulp Macrophages Regulate CD4 T Cell Responses
Results suggested that splenic CSF-1–dependent F4/80hiMac-1low MΦs are a subpopulation of RPMs and regulate peripheral immune homeostasis. Expand
Regulation of basophil and mast cell development by transcription factors.
An overview of recent advances in understanding of how transcription factors regulate the development of basophils and mast cells is provided. Expand
Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress
Significance The lymphatic system plays critical roles in immune surveillance by providing a route for circulating immune cells. α9 integrin is a signature molecule of lymphatic endothelial cellsExpand