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Oxidative stress in ulcerative colitis-associated carcinogenesis.
Oxidative stress is defined as an imbalance between generation of reactive oxygen species (ROS) and decreased antioxidant defense systems. Oxidative stress develops particularly in inflammatoryExpand
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Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models
We have shown that thymoquinone (TQ) is a potent antitumor agent in human colorectal cancer cells. In this study, we evaluated TQ's therapeutic potential in two different mice colon cancer models [Expand
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K-ras mutation detection in colorectal cancer using the Pyrosequencing technique.
The identification of gene mutations is a critical goal for the assessment of diagnosis and prognosis in cancer disease, particularly by direct sequencing. Pyrosequencing is a straightforward,Expand
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Inflammation and Barrett's carcinogenesis.
Barrett's esophagus (BE) is one of the most common premalignant lesions in which normal squamous epithelium of the esophagus is replaced by metaplastic columnar epithelium. Esophageal adenocarcinomaExpand
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Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells.
There are few reports describing the role of p53-dependent gene repression in apoptotic cell death. To identify such apoptosis-associated p53 target genes, we used the pro-oxidant plant-derived drugExpand
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Hypermethylation and loss of expression of glutathione peroxidase-3 in Barrett's tumorigenesis.
Chronic gastroesophageal reflux disease is a known risk factor for Barrett's esophagus (BE), which induces oxidative mucosal damage. Glutathione peroxidase-3 (GPx3) is a secretory protein with potentExpand
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Proteinase-Activated Receptor-2 in the Pathogenesis of Gastroesophageal Reflux Disease
OBJECTIVES:The proteinase-activated receptor-2 (PAR-2) is activated by serine proteases and has been demonstrated to induce proinflammatory and neuroinflammatory effects. It is considered to alterExpand
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Serological assessment of gastric mucosal atrophy in gastric cancer
BackgroundNon-invasive tools for gastric cancer screening and diagnosis are lacking. Serological testing with the detection of pepsinogen 1 (PG1), pepsinogen 2 (PG2) and gastrin 17 (G17) offers theExpand
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Intralesional fibrous septum in chordoma: a clinicopathologic and immunohistochemical study of 122 lesions.
Intralesional fibrous septum (IFS) generally is considered a reactive tissue in chordoma; however, little is known about its significance. We studied 122 chordomas for IFS using immunohistochemicalExpand
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Skull base and nonskull base chordomas
To the authors' knowledge, little is known regarding the relation between the proliferative ability and clinicopathologic parameters in skull base chordomas (SBCs) and nonskull base chordomas (NSBCs).
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