D. Kostálová

Publications47
h-index18
Citations1,388
Highly Influential Citations37
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Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids
Roots and stem-bark of Mahonia aquifolium (Oregon grape) (Berberidaceae) are effectively used in the treatment of skin inflammatory conditions.In the present study, the effect of Mahonia aquifolium… Expand
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Antifungal activity of Mahonia aquifolium extract and its major protoberberine alkaloids
The crude extract of Mahonia aquifolium (Berberidaceae) stem bark and its components berberine, palmatine and jatrorrhizine were screened for their inhibitory activity against a variety of… Expand
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Antiradical and antioxidant activities of alkaloids isolated from Mahonia aquifolium. Structural aspects.
The antioxidant activities of three alkaloids isolated from Mahonia aquifolium--berberine, jatrorrhizine, and magnoflorine--were studied with respect to their structural aspects, particularly the… Expand
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Oxidation of liposomal membrane suppressed by flavonoids: quantitative structure-activity relationship.
Antioxidant activity of the set of 12 flavonoids in heterogeneous membrane system of dioleoyl phosphatidylcholine liposomes stressed by peroxidative damage induced by… Expand
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Antiprotease and Antimetastatic Activity of Ursolic Acid Isolated from Salvia officinalis
Abstract Proteases play a regulatory role in a variety of pathologies including cancer, pancreatitis, thromboembolic disorders, viral infections and many others. One of the possible strategies how to… Expand
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Effect of Mahonia aquifolium active compounds on interleukin-8 production in the human monocytic cell line THP-1.
The effect of the crude extract and of two alkaloid fractions prepared from Mahonia aquifolium on interleukin-8 (IL-8) production in the lipopolysaccharide (LPS)-stimulated human monocytic cell line… Expand
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Lipoxygenase inhibition and antioxidant properties of protoberberine and aporphine alkaloids isolated from Mahonia aquifolium.
Products of lipoxygenase metabolism play a role in the pathogenesis of psoriasis. Four protoberberine alkaloids, berberine, oxyberberine, jatrorrhizine, columbamine, and two aporphine alkaloids,… Expand
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Lipoxygenase inhibition and antioxidant properties of bisbenzylisoqunoline alkaloids isolated from Mahonia aquifolium.
Products of lipoxygenase metabolism are known to play a role in the pathogenesis of psoriasis. Six bisbenzylisoquinoline (BBIQ) alkaloids, oxyacanthine, armoline, baluchistine, berbamine, obamegine,… Expand
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Antimicrobial activity of Mahonia aquifolium crude extract and its major isolated alkaloids
The crude extract of Mahonia aquifolium (Pursh) Nutt. stem bark and its two main protoberberine alkaloids, berberine and jatrorrhizine, were tested for their in vitro antimicrobial activity. Twenty… Expand
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Mechanism of anti-inflammatory action of liquorice extract and glycyrrhizin
The antiradical activity, protective effect against lipid peroxidation of liposomal membrane, and inhibitory effect on whole blood reactive oxygen species (ROS) liberation of Glycyrrhiza glabra crude… Expand
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