D. Knopman

Publications1,571
h-index156
Citations104,943
Highly Influential Citations3,965
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The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
TLDR
The workgroup sought to ensure that the revised criteria would be flexible enough to be used by both general healthcare providers without access to neuropsychological testing, advanced imaging, and cerebrospinal fluid measures, and specialized investigators involved in research or in clinical trial studies who would have these tools available.
Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
TLDR
It is found that repeat expansion in C9ORF72 is a major cause of both FTD and ALS, suggesting multiple disease mechanisms.
Classification of primary progressive aphasia and its variants
This article provides a classification of primary progressive aphasia (PPA) and its 3 main variants to improve the uniformity of case reporting and the reliability of research results. Criteria for…
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
TLDR
This work proposes a model that relates disease stage to AD biomarkers in which Abeta biomarkers become abnormal first, before neurodegenerative biomarkers and cognitive symptoms, and neurodegnerative biomarker become abnormal later, and correlate with clinical symptom severity.
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia.
TLDR
The revised criteria for behavioural variant frontotemporal dementia improve diagnostic accuracy compared with previously established criteria in a sample with known frontotmporal lobar degeneration and reflect the optimized diagnostic features, less restrictive exclusion features and a flexible structure that accommodates different initial clinical presentations.
Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
TLDR
It is speculated that the two major proteinopathies underlying AD biomarker changes, amyloid β (Aβ) and tau, might be initiated independently in sporadic AD, in which it is hypothesised that an incident Aβ pathophysiology can accelerate antecedent limbic and brainstem tauopathy.
Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
TLDR
A broad consensus now exists that these criteria for the clinical diagnosis of Alzheimer's disease should be revised to incorporate state‐of‐the‐art scientific knowledge.
Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy
TLDR
PCA is a distinctive dementia syndrome in which the most pronounced pathologic involvement is in the occipitoparietal regions independent of the specific underlying pathology.
Mild cognitive impairment: ten years later.
TLDR
This review summarizes the progress that has been made while also recognizing the challenges that remain and outlines the priorities for further research into mild cognitive impairment.
Practice parameter: Diagnosis of dementia (an evidence-based review)
TLDR
D diagnostic criteria for dementia have improved since the 1994 practice parameter, and further research is needed to improve clinical definitions of dementia and its subtypes, as well as to determine the utility of various instruments of neuroimaging, biomarkers, and genetic testing in increasing diagnostic accuracy.
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