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Multiple imputation of missing blood pressure covariates in survival analysis.
This paper studies a non-response problem in survival analysis where the occurrence of missing data in the risk factor is related to mortality. In a study to determine the influence of blood pressureExpand
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The definition of anemia in older persons.
CONTEXT Whether hemoglobin concentrations defined as anemia by the World Health Organization (WHO) are associated with increased mortality in older persons is not known. OBJECTIVE To investigateExpand
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Successful aging in the oldest old: Who can be characterized as successfully aged?
BACKGROUND Successful aging is a worldwide aim, but it is less clear which indicators characterize elderly persons as successfully aged. We explored the meaning of successful aging from 2Expand
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Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo.
To study gene mutations in different organs and tissues of an experimental animal, we produced transgenic mice harboring bacteriophage lambda shuttle vectors integrated in the genome in aExpand
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Cell biology and kinetics of Kupffer cells in the liver.
Publisher Summary The study of Kupffer cells has developed rapidly and has been extended to problems concerning the origin, structure, and function of these cells in normal and pathologicalExpand
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Relation between localization and function of rat liver Kupffer cells.
  • E. Sleyster, D. Knook
  • Biology, Medicine
  • Laboratory investigation; a journal of technical…
  • 1 November 1982
Kupffer cells were found to be distributed over zone 1 (periportal), zone 2 (midzonal), and zone 3 (perivenous) of the rat liver acinus in a ratio of 4:3:2. After pronase digestion of the liver, twoExpand
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Isolation and characterization of Kupffer and endothelial cells from the rat liver.
Abstract Non-parenchymal cell suspensions were prepared from rat livers by three different methods based on a collagenase, a pronase and a combined collagenase-pronase treatment. The highest yield ofExpand
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Comparative endotoxin‐induced hepatic injury in young and aged rats
Recent studies have demonstrated that aged rats are more susceptible to the lethal effects of endotoxin (ET) than young rats. The early (15 min to 7 h) hepatic ultrastructural and biochemical changesExpand
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Association of the tumour necrosis factor α −308G/A polymorphism with the risk of diabetes in an elderly population-based cohort
Ample evidence supports a role for tumour necrosis factor α (TNFα) in the development of type 2 diabetes and cardiovascular disease. TNFα expression was found to be influenced by a −308G/AExpand
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Purified Rat Liver Fat‐Storing Cells in Culture Divide and Contain Collagen
Primary cultures and cell lines were established from suspensions of purified fat‐storing cells isolated from the rat liver. When seeded at a suitable density, fat‐storing cells in primary cultureExpand
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