Skip to search formSkip to main contentSkip to account menu
Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis.
TLDR
It is demonstrated that TLR2 mediates the inflammatory cytokine response to HSV-1 by using both transfected cell lines and knockout mice, and these studies suggest theTLR2-mediated cytokineresponse to HSv-1 is detrimental to the host.
View on PubMed
Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein
TLDR
A pathway for nuclear innate sensing of HSV DNA by IFI16 in infected HFF is defined and a mechanism by which a virus can block this nuclear innate response is document.
View on Publisher
Proteomics of Herpes Simplex Virus Replication Compartments: Association of Cellular DNA Replication, Repair, Recombination, and Chromatin Remodeling Proteinswith ICP8
TLDR
It is hypothesize that some of the proteins coprecipitating with ICP8 are involved in HSV replication and may give new insight into viral replication mechanisms.
View on ASMUSA
Genetic evidence for two distinct transactivation functions of the herpes simplex virus alpha protein ICP27
TLDR
Infected-cell protein 27 (ICP27) is a herpes simplex virus type 1 alpha, or immediate-early, protein involved in the regulation of viral gene expression that mediates two distinct transactivation functions, one which stimulates gamma-1 gene expression and a second one required for gamma-2 gene induction.
View on ASMUSA
Chromatin control of herpes simplex virus lytic and latent infection
TLDR
A model for the decision to undergo a lytic or a latent infection in which HSV encodes gene products that modulate chromatin structure towards either euchromatin or heterochromatin is proposed and the implications for the development of therapeutics for HSV infections are discussed.
View on Nature
Formation of DNA replication structures in herpes virus-infected cells requires a viral DNA binding protein
View on Elsevier
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection
TLDR
It is shown that vaginal instillation of small interfering RNAs (siRNAs) targeting HSV-2 protects mice from lethal infection and suggests that siRNAs are attractive candidates for the active component of a microbicide designed to prevent viral infection or transmission.
View on Springer
Vaginal Submucosal Dendritic Cells, but Not Langerhans Cells, Induce Protective Th1 Responses to Herpes Simplex Virus-2
TLDR
A previously unanticipated role for submucosal DCs is demonstrated in the generation of protective Th1 immune responses to HSV-2 in the vaginal mucosa, and their importance in immunity to other sexually transmitted diseases is suggested.
View PDF
Numerous Conserved and Divergent MicroRNAs Expressed by Herpes Simplex Viruses 1 and 2
TLDR
The results reveal elements of miRNA conservation and divergence that should aid in identifying miRNA functions, and identify a highly conserved miRNA family arising from the viral origins of replication.
View on ASMUSA
Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.
TLDR
It is suggested that acyclovir-resistant viruses could establish latent infections in clinical settings and have implications for the use of genetically engineered herpesviruses to deliver foreign genes to neurons.
View on PubMed
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License