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Insulin attenuates the systemic inflammatory response in endotoxemic rats.
Insulin decreases the mortality and prevents the incidence of infection and sepsis in critically ill patients. The molecular and cellular mechanisms by which insulin improves survival have not beenExpand
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Extensive MHC variability in cichlid fishes of Lake Malawi
LAKE Malawi in East Africa harbours 500–1,000 endemic species of cichlid fishes, all presumably derived by adaptive radiation from a single founding population within the past two million years1–3.Expand
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Insulin Treatment Improves the Systemic Inflammatory Reaction to Severe Trauma
Objective:Determine the effect of insulin on the systemic inflammatory response, pro- and anti-inflammatory cytokines and hepatic acute-phase-response in severely burned pediatric patients. SummaryExpand
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Targeting Heat Shock Protein 90 in Pancreatic Cancer Impairs Insulin-like Growth Factor-I Receptor Signaling, Disrupts an Interleukin-6/Signal-Transducer and Activator of Transcription
Purpose: Inhibitors of heat-shock protein 90 (Hsp90) may interfere with oncogenic signaling pathways, including Erk, Akt, and hypoxia-inducible factor-1α (HIF-1α). Because insulin-like growthExpand
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Inhibition of heat shock protein 90 impairs epidermal growth factor–mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo
Oncogenic signaling through activation of epidermal growth factor receptor (EGFR), HER-2, and hypoxia inducible-factor-1α (HIF-1α) has been implicated in gastric cancer growth and angiogenesisExpand
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Specific downregulation and mistargeting of the lipid raft-associated protein MAL in a glycolipid storage disorder
Metachromatic leukodystrophy (MLD) is a lysosomal lipid storage disease caused by arylsulfatase A deficiency. In MLD patients the sphingolipid sulfatide increasingly accumulates leading toExpand
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Studies of adenovirus-induced eye disease in the rabbit model.
PURPOSE To achieve a better understanding of the pathogenic processes associated with human adenovirus (Ad)-induced ocular disease. METHODS Growth curves of Ad5 and Ad14 were performed in cellExpand
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Insulin Attenuates the Systemic Inflammatory Response to Thermal Trauma
BackgroundInsulin has been recently shown to decrease mortality and prevent the incidence of multi-organ failure in critically ill patients. The molecular mechanisms by which insulin improvesExpand
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Mammalian target of rapamycin is activated in human gastric cancer and serves as a target for therapy in an experimental model
The mammalian target of rapamycin (mTOR) has become an interesting target for cancer therapy through its influence on oncogenic signals, which involve phosphatidylinositol‐3‐kinase andExpand
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Characterization of pancreatic ductal cells in human islet preparations
Substantial amounts of nonendocrine cells are implanted as part of human islet grafts, and a possible influence of nonendocrine cells on clinical islet transplantation outcome has been postulated.Expand
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