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T-lymphocyte T4 molecule behaves as the receptor for human retrovirus  LAV
TLDR
Preincubation of T4+ lymphocytes with three individual monoclonal antibodies directed at the T4 glycoprotein blocked cell infection by LAV, strongly support the view that a surface molecule directly involved in cellular functions acts as, or is related to, the receptor for a human retrovirus. Expand
A novel dendritic cell subset involved in tumor immunosurveillance
TLDR
Adoptive transfer of these IFN-producing killer dendritic cells into tumor-bearing Rag2/−Il2rg−/− mice prevented tumor outgrowth, whereas transfer of conventional NK cells did not and was identified as pivotal sensors and effectors of the innate antitumor immune response. Expand
Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia.
TLDR
It is shown that regulatory T cells specific for recipient-type alloantigens control GVHD while favoring immune reconstitution, suggesting that recipient- type specific Treg's could be preferentially used in the control of GV HD in future clinical trials. Expand
Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus
TLDR
There is a close phylogenetic relationship between the conserved reverse transcriptase and endonuclease/integrase domains of the visna and AIDS viruses and the inclusion of the AIDS virus in the retroviral subfamily Lentivirinae is supported. Expand
IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells
TLDR
It is shown that 5 d of low-dose IL-2 administration starting at the time of T1D onset can reverse established disease in NOD (nonobese diabetic) mice, with long-lasting effects. Expand
Continuous Activation of Autoreactive CD4+ CD25+ Regulatory T Cells in the Steady State
TLDR
The results reveal the existence of a cycling Treg subset composed of autoreactive Treg that are continuously activated by tissue self-antigens. Expand
Natural regulatory T cells control the development of atherosclerosis in mice
TLDR
It is shown that naturally arising CD4+CD25+ regulatory T cells, which actively maintain immunological tolerance to self and nonself antigens, are powerful inhibitors of atherosclerosis in several mouse models. Expand
Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis.
TLDR
The trial showed that low-dose interleukin-2 was not associated with adverse effects and led to Treg recovery and concomitant clinical improvement in patients with HCV-induced vasculitis, an autoimmune condition. Expand
Heterogeneity of mouse spleen dendritic cells: in vivo phagocytic activity, expression of macrophage markers, and subpopulation turnover.
TLDR
The present results indicate that marginal DC and IDC represent two essentially distinct populations of DC in the mouse spleen, which differ not only in location, but also in phenotype, phagocytic ability, and turnover. Expand
CD4+CD25+ Immunoregulatory T Cells
TLDR
It is shown that the few CD4+CD25+ T cells naturally present in the transplant regulate GVHD because their removal from the graft dramatically accelerates this disease. Expand
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