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- Publications
- Influence
Extensive allelic variation and ultrashort telomeres in senescent human cells
- D. Baird, J. Rowson, D. Wynfordthomas, D. Kipling
- Biology, Medicine
- Nature Genetics
- 1 February 2003
By imposing a limit on the proliferative lifespan of most somatic cells, telomere erosion represents an innate mechanism for tumor suppression and may contribute to age-related disease. A detailed… Expand
Telomere instability in the male germline.
- D. Baird, B. Britt-Compton, J. Rowson, N. Amso, L. Gregory, D. Kipling
- Biology, Medicine
- Human molecular genetics
- 2006
Telomeres play a key role in upholding the integrity of the genome, and telomerase expression in spermatogonial stem cells is responsible for the maintenance of telomere length in the human male… Expand
High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations.
- Y. Wu, D. Kipling, H. S. Leong, Victoria G. Martin, A. Ademokun, D. Dunn-Walters
- Biology, Medicine
- Blood
- 19 August 2010
B-cell receptor (BCR) diversity is achieved centrally by rearrangement of Variable, Diversity, and Joining genes, and peripherally by somatic hypermutation and class-switching of the rearranged… Expand
Structural stability and chromosome-specific telomere length is governed by cis-acting determinants in humans.
- B. Britt-Compton, J. Rowson, Matthew Locke, I. Mackenzie, D. Kipling, D. Baird
- Biology, Medicine
- Human molecular genetics
- 1 March 2006
Single telomere length analysis (STELA) of the XpYp telomere has revealed extensive allelic variation and ultra-short telomeres in senescent cells. Superimposed on end-replication losses are… Expand
Reversible Senescence in Human CD4+CD45RA+CD27− Memory T Cells
- Diletta Di Mitri, R. Azevedo, +7 authors A. Akbar
- Biology, Medicine
- The Journal of Immunology
- 1 September 2011
Persistent viral infections and inflammatory syndromes induce the accumulation of T cells with characteristics of terminal differentiation or senescence. However, the mechanism that regulates the… Expand
Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts
- F. Wyllie, C. Jones, +5 authors D. Kipling
- Biology, Medicine
- Nature Genetics
- 2000
Werner syndrome (WS) is a rare disorder inherited in an autosomal recessive manner and characterized by accelerated ageing. WS fibroblasts display an accelerated rate of senescence in vitro, which… Expand
Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity
- Zahra Sabouri, P. Schofield, +13 authors C. Goodnow
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 12 May 2014
Significance Antibodies are selected to bind microbial but not self-antigens, because binding to self would compete with binding microbes, shorten antibody half-life, and cause autoimmunity.… Expand
The Relationship between CD27 Negative and Positive B Cell Populations in Human Peripheral Blood
- Y. Wu, D. Kipling, D. Dunn-Walters
- Biology, Medicine
- Front. Immun.
- 16 November 2011
CD27 expression has been used to distinguish between memory and naive B cells in humans. However, low levels of mutated and isotype-switched CD27−IgD− cells are seen in healthy adults, and these are… Expand
Human telomerase reverse transcriptase-immortalized MRC-5 and HCA2 human fibroblasts are fully permissive for human cytomegalovirus.
- B. McSharry, C. J. Jones, J. W. Skinner, D. Kipling, G. Wilkinson
- Biology, Medicine
- The Journal of general virology
- 1 April 2001
MRC-5 cells are a well-characterized human diploid fibroblast cell line approved for vaccine production and favoured for the routine propagation of human cytomegalovirus (HCMV). Ectopic expression of… Expand
Centromeres, CENP-B and Tigger too.
- D. Kipling, P. Warburton
- Biology, Medicine
- Trends in genetics : TIG
- 1 April 1997
The highly conserved centromere-associated protein CENP-B is a common feature of mammalian centromeres. Binding sites for CENP-B, so-called 'CENP-B boxes', are present in the otherwise unrelated… Expand