• Publications
  • Influence
Extensive allelic variation and ultrashort telomeres in senescent human cells
By imposing a limit on the proliferative lifespan of most somatic cells, telomere erosion represents an innate mechanism for tumor suppression and may contribute to age-related disease. A detailedExpand
  • 474
  • 37
Telomere instability in the male germline.
Telomeres play a key role in upholding the integrity of the genome, and telomerase expression in spermatogonial stem cells is responsible for the maintenance of telomere length in the human maleExpand
  • 140
  • 20
  • PDF
High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations.
B-cell receptor (BCR) diversity is achieved centrally by rearrangement of Variable, Diversity, and Joining genes, and peripherally by somatic hypermutation and class-switching of the rearrangedExpand
  • 250
  • 13
Structural stability and chromosome-specific telomere length is governed by cis-acting determinants in humans.
Single telomere length analysis (STELA) of the XpYp telomere has revealed extensive allelic variation and ultra-short telomeres in senescent cells. Superimposed on end-replication losses areExpand
  • 121
  • 10
  • PDF
Reversible Senescence in Human CD4+CD45RA+CD27− Memory T Cells
Persistent viral infections and inflammatory syndromes induce the accumulation of T cells with characteristics of terminal differentiation or senescence. However, the mechanism that regulates theExpand
  • 164
  • 9
Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts
Werner syndrome (WS) is a rare disorder inherited in an autosomal recessive manner and characterized by accelerated ageing. WS fibroblasts display an accelerated rate of senescence in vitro, whichExpand
  • 337
  • 8
Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity
Significance Antibodies are selected to bind microbial but not self-antigens, because binding to self would compete with binding microbes, shorten antibody half-life, and cause autoimmunity.Expand
  • 144
  • 8
  • PDF
The Relationship between CD27 Negative and Positive B Cell Populations in Human Peripheral Blood
CD27 expression has been used to distinguish between memory and naive B cells in humans. However, low levels of mutated and isotype-switched CD27−IgD− cells are seen in healthy adults, and these areExpand
  • 113
  • 8
  • PDF
Human telomerase reverse transcriptase-immortalized MRC-5 and HCA2 human fibroblasts are fully permissive for human cytomegalovirus.
MRC-5 cells are a well-characterized human diploid fibroblast cell line approved for vaccine production and favoured for the routine propagation of human cytomegalovirus (HCMV). Ectopic expression ofExpand
  • 76
  • 8
Centromeres, CENP-B and Tigger too.
The highly conserved centromere-associated protein CENP-B is a common feature of mammalian centromeres. Binding sites for CENP-B, so-called 'CENP-B boxes', are present in the otherwise unrelatedExpand
  • 187
  • 7