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The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.
It is demonstrated thatosphorylation of beta-catenin in vivo requires an in vitro amino-terminal Xgsk-3 phosphorylation site, which is conserved in the Drosophila protein armadillo, which provides a basis for understanding the interaction between XgSk-3 and beta-catsin in the establishment of the dorsal-ventral axis in early Xenopus embryos. Expand
β-Catenin destruction complex: insights and questions from a structural perspective
This work suggests a working model for the destruction complex based on the existing structural and experimental data, and focuses on the questions that this model and other studies have raised about the function of the complex in both the normal and Wnt-inhibited states. Expand
A homeobox gene essential for zebrafish notochord development
It is shown that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord, and it is proposed that flh regulates notochords precursor cell fate. Expand
GBP, an Inhibitor of GSK-3, Is Implicated in Xenopus Development and Oncogenesis
GBP inhibits in vivo phosphorylation by Xgsk-3, and ectopic GBP expression induces an axis by stabilizing beta-catenin within Xenopus embryos by antisense oligonucleotide depletion of the maternal GBP mRNA demonstrates that GBP is required for the establishment of the dorsal-ventral axis in Xenopus embryo. Expand
Canonical Wnt signaling dynamically controls multiple stem cell fate decisions during vertebrate body formation.
It is demonstrated that dynamic local Wnt signaling cues specify germ layer contribution and mesodermal tissue type specification of multipotent stem cells throughout the formation of the early vertebrate embryonic body. Expand
A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus.
The Wnt pathway regulates the early dorsal-ventral axis in Xenopus through a complex of beta-catenin and HMG box transcription factors of the Lef/Tcf family. We show that the promoter of theExpand
Molecular identification of spadetail: regulation of zebrafish trunk and tail mesoderm formation by T-box genes.
It is shown that the regulatory hierarchy among spadetail, no tail and a third T-box gene, tbx6, are substantially different during trunk and tail mesoderm formation, and a genetic model is proposed that accounts for the regional phenotypes of spadETail and no tail mutants. Expand
Localized BMP-4 mediates dorsal/ventral patterning in the early Xenopus embryo.
It is suggested that BMP-4 may act to oppose the action of dorsalizing signals and neural-inducing signals that originate in the dorsal organizer region and may have an analogous role to the Drosophila gene, dpp, in dorsal/ventral pattern formation. Expand
XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development.
The data support a role for XCTBP as a co-repressor throughout Xenopus development and indicate that XCtBP/G4A will be a useful tool in determining how XCt BP functions in various developmental processes. Expand
Regulation of canonical Wnt signaling by Brachyury is essential for posterior mesoderm formation.
Using cell transplantation, it is shown that the only essential role for Brachyury during somite formation is non-cell autonomous, and that Ntl and Bra are required for and can induce expression of the canonical Wnts wnt8 and wnt3a. Expand