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Degradation of diclofenac by pyrite catalyzed Fenton oxidation
Abstract We demonstrated that diclofenac can be rapidly and completely oxidized in Fenton reaction system using pyrite as catalyst. The pH of the solution dropped from 5.7 to 4.1–3.2 with addition ofExpand
Superparamagnetic iron oxide nanoparticles as a dual imaging probe for targeting hepatocytes in vivo
TLDR
The dual probe SPION detectable by both nuclear and MR imaging modality for specifically targeting hepatocytes in vivo is synthesized and characterized and demonstrated that the lactobionic acid‐SPION were localized in hepatocytes. Expand
F-18 labeling protocol of peptides based on chemically orthogonal strain-promoted cycloaddition under physiologically friendly reaction conditions.
TLDR
High-throughput synthesis of various (18)F-labeled peptide tracers by a straightforward protocol based on a chemo-orthogonal strain-promoted alkyne azide cycloaddition (SPAAC) to develop peptide based positron emission tomography (PET) molecular imaging probes is introduced. Expand
F-18 Labeled RGD Probes Based on Bioorthogonal Strain-Promoted Click Reaction for PET Imaging.
TLDR
In vivo PET imaging study and biodistribution data showed that this radiotracer allowed successful visualization of tumors with good tumor-to-background contrast and significantly higher tumor uptake compared to other major organs. Expand
Hydrothermal catalytic processing of saturated and unsaturated fatty acids to hydrocarbons with glycerol for in situ hydrogen production
Lipids are a promising feedstock to produce renewable hydrocarbon fuels and H2via catalytic hydrothermal processing. Upon exposure to hydrothermal media (e.g., 300 °C, 8–11 MPa), lipids rapidlyExpand
A new class of SN2 reactions catalyzed by protic solvents: Facile fluorination for isotopic labeling of diagnostic molecules.
TLDR
This work introduces a remarkable effect of using tertiary alcohols as a reaction medium for nucleophilic fluorination with alkali metal fluorides, greatly increasing the rate of the nucleophile fluorination and reducing formation of byproducts compared with conventional methods using dipolar aprotic solvents. Expand
Facile nucleophilic fluorination reactions using tert-alcohols as a reaction medium: significantly enhanced reactivity of alkali metal fluorides and improved selectivity.
TLDR
This work found that fluorination of 1-(2-mesyloxyethyl)naphthalene and N-5-bromopentanoyl-3,4-dimethoxyaniline with Bu(4)N(+)F(-) in a tert-alcohol afforded the corresponding fluoro products in much higher yield than obtained by the conventional methods using dipolar aprotic solvents. Expand
Characterization of the pharmacophore properties of novel selective estrogen receptor downregulators (SERDs).
TLDR
Although most structural variants showed binding affinities for ERalpha and ERbeta higher than that of 4, only the compounds preserving the acrylic acid side chain retained SERD activity, although they could possess varying core structures. Expand
Fluorine-substituted cyclofenil derivatives as estrogen receptor ligands: synthesis and structure-affinity relationship study of potential positron emission tomography agents for imaging estrogen
TLDR
Binding assays to both ERalpha and ERbeta revealed that the C3 site is more tolerant of steric bulk and polar groups than the C4 site, consistent with a computational model of the ERalpha ligand binding pocket. Expand
In vivo imaging of mesenchymal-epithelial transition factor (c-Met) expression using an optical imaging system.
TLDR
Results suggest that Cy5.5-conjugated cMBP could potentially be used to detect c-Met-positive cancers in vivo, however, additional modifications to this optical imaging agent are needed to further improve its efficacy. Expand
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