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Local and Distant Immunity Induced by Intralesional Vaccination with an Oncolytic Herpes Virus Encoding GM-CSF in Patients with Stage IIIc and IV Melanoma
- H. L. Kaufman, D. Kim, G. Deraffele, J. Mitcham, R. Coffin, S. Kim-schulze
- Annals of Surgical Oncology
- 1 March 2010
BackgroundAn oncolytic herpes simplex virus engineered to replicate selectively in tumor cells and to express granulocyte–macrophage colony-stimulating factor (GM-CSF) was tested as a direct… Expand
Intravenous Transplants of Human Adipose-Derived Stem Cell Protect the Brain from Traumatic Brain Injury-Induced Neurodegeneration and Motor and Cognitive Impairments: Cell Graft Biodistribution and…
Traumatic brain injury (TBI) survivors exhibit motor and cognitive symptoms from the primary injury that can become aggravated over time because of secondary cell death. In the present in vivo study,… Expand
AtObgC, a plant ortholog of bacterial Obg, is a chloroplast-targeting GTPase essential for early embryogenesis
Obg is a ribosome-associated GTPase essential for bacterial viability and is conserved in most organisms, from bacteria to eukaryotes. Obg is also expressed in plants, which predicts an important… Expand
Increased stress-induced generation of reactive oxygen species and apoptosis in human keratoconus fibroblasts.
- M. Chwa, Shari R. Atilano, V. Reddy, N. Jordan, D. Kim, M. Kenney
- Biology, Medicine
- Investigative ophthalmology & visual science
- 1 May 2006
PURPOSE To determine whether keratoconus (KC) corneal fibroblast cultures have increased reactive oxygen species (ROS) production and are more susceptible to stress-related challenges. METHODS… Expand
Genomic organization, tissue distribution and deletion mutation of human pyridoxine 5'-phosphate oxidase.
- J. Kang, Mi-Lim Hong, +7 authors O. Kwon
- Biology, Medicine
- European journal of biochemistry
- 1 June 2004
We used a combined computer and biochemical approach to characterize human pyridoxine 5'-phosphate oxidase (PNPO). The human PNPO gene is composed of seven exons and six introns, and spans… Expand
Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy.
- M. Sabatino, S. Kim-schulze, +8 authors H. Kaufman
- Journal of clinical oncology : official journal…
- 1 June 2009
PURPOSE High-dose interleukin-2 (IL-2) induces durable therapeutic responses in a small subset of patients with metastatic melanoma and renal cell carcinoma, but simple pretreatment predictors of… Expand
Tat-glyoxalase protein inhibits against ischemic neuronal cell damage and ameliorates ischemic injury.
Methylglyoxal (MG), a metabolite of glucose, is the major precursor of protein glycation and induces apoptosis. MG is associated with neurodegeneration, including oxidative stress and impaired… Expand
Role of Arabidopsis CHL27 protein for photosynthesis, chloroplast development and gene expression profiling.
In Chl biosynthesis, aerobic Mg-protoporphyrin IX monomethyl ester (MPE) cyclase is a key enzyme involved in the synthesis of protochlorophyllide a, and its membrane-bound component is known to be… Expand
Molecular Cytogenetic Analysis of Gene Rearrangements in Childhood Acute Lymphoblastic Leukemia
- H. Y. Woo, D. Kim, H. Park, K. W. Seong, H. Koo, S. H. Kim
- Biology, Medicine
- Journal of Korean medical science
- 1 February 2005
The aims of this study were to estimate the incidences of BCR/ABL, MLL, TEL/AML1 rearrangements, and p16 deletions in childhood acute lymphoblastic leukemia (ALL), to identify new abnormalities, and… Expand
Poxvirus-based vaccine therapy for patients with advanced pancreatic cancer
- H. L. Kaufman, S. Kim-schulze, +5 authors J. Marshall
- Journal of Translational Medicine
- 26 November 2007
PurposeAn open-label Phase 1 study of recombinant prime-boost poxviruses targeting CEA and MUC-1 in patients with advanced pancreatic cancer was conducted to determine safety, tolerability and obtain… Expand