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The FNIH Sarcopenia Project: Rationale, Study Description, Conference Recommendations, and Final Estimates
Background. Low muscle mass and weakness are common and potentially disabling in older adults, but in order to become recognized as a clinical condition, criteria for diagnosis should be based onExpand
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Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wideExpand
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Twenty bone mineral density loci identified by large-scale meta-analysis of genome-wide association studies
Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of osteoporosis and the assessment of fracture risk. We performed meta-analysis of five genome-wide associationExpand
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Risk Factors for Longitudinal Bone Loss in Elderly Men and Women: The Framingham Osteoporosis Study
Few studies have evaluated risk factors for bone loss in elderly women and men. Thus, we examined risk factors for 4‐year longitudinal change in bone mineral density (BMD) at the hip, radius, andExpand
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Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials.
BACKGROUND Antifracture efficacy with supplemental vitamin D has been questioned by recent trials. METHODS We performed a meta-analysis on the efficacy of oral supplemental vitamin D in preventingExpand
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Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials
Objective To test the efficacy of supplemental vitamin D and active forms of vitamin D with or without calcium in preventing falls among older individuals. Data sources We searched Medline, theExpand
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Cutpoints for Low Appendicular Lean Mass That Identify Older Adults With Clinically Significant Weakness
Background. Low lean mass is potentially clinically important in older persons, but criteria have not been empirically validated. As part of the FNIH (Foundation for the National Institutes ofExpand
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Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women.
BACKGROUND Osteoporosis and related fractures will be growing public health problems as the population ages. It is therefore of great importance to identify modifiable risk factors. OBJECTIVE WeExpand
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Epigenetic Signatures of Cigarette Smoking
Background—DNA methylation leaves a long-term signature of smoking exposure and is one potential mechanism by which tobacco exposure predisposes to adverse health outcomes, such as cancers,Expand
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New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up study.
The purpose of the present study was to assess the location, severity and progression of radiopaque lumbar aortic calcifications and to evaluate the utility of summary scores of lumbar calcificationExpand
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