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Vitamin C mediated protection on cisplatin induced mutagenicity in mice.
In present studies the development of chromosomal aberrations, micronuclei in bone marrow cells and sperm head abnormalities were used as mutagenic bioassay in Swiss albino mice treated with… Expand
Effect of cisplatin on mitochondrial protein, glutathione, and succinate dehydrogenase in Dalton lymphoma-bearing mice
Cisplatin treatment of tumor-bearing mice resulted a significant decrease of protein in the tissues studied (liver, kidney, and Dalton lymphoma) and also in their mitochondrial fractions. As compared… Expand
Cisplatin-induced genotoxic effects and endogenous glutathione levels in mice bearing ascites Dalton's lymphoma.
cis-Diaminedichloroplatinum(II), commonly known as cisplatin, treatment of mice for 24-96, 30 h and 10 days caused the development of chromosomal aberrations in bone marrow cells as well as in… Expand
Changes in endogenous tissue glutathione level in relation to murine ascites tumor growth and the anticancer activity of cisplatin.
Changes in glutathione levels were determined in tissues of 11- to 12-week-old Swiss albino mice at different stages of Dalton's lymphoma tumor growth and following cisplatin (8 mg/kg body weight,… Expand
Changes in glutathione-related enzymes in tumor-bearing mice after cisplatin treatment
The effect of cisplatin on five glutathione-related enzymes was studied in liver, kidney, and Dalton lymphoma cells of tumor-bearing mice. In liver, the activities of glutathione S-transferase,… Expand
Hematotoxicity and blood glutathione levels after cisplatin treatment of tumor-bearing mice
The involvement of glutathione, a major cellular antioxidant, in cisplatin-mediated development of various hematological changes in mice bearing ascites Dalton lymphoma tumor was investigated. With… Expand
CISPLATIN-MEDIATED ENZYMATIC CHANGES IN MICE BEARING ASCITES DALTON'S LYMPHOMA
Effect of cisplatin on Allium cepa root meristem cells.
Allium cepa root growth was retarded by cisplatin treatment in a dose-dependent manner. A decrease in the mitotic index (MI) and an increase in the number of interphase cells was seen in cisplatin… Expand
STUDIES ON THE CHROMOSOMES OF MURINE DALTON'S LYMPHOMA CELLS AND THE EFFECT OF CISPLATIN ON CHROMOSOMES OF THESE CELLS AND BONE MARROW CELLS IN VIVO
Chromosome studies of Dalton's lymphoma (DL) revealed only one rb-marker in the cells and the chromosome numbers varied between 59 and 68 with a peak at 66 chromosomes. Thus, the modal number of… Expand