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Isolation Rearing in Rats: Pre- and Postsynaptic Changes in Striatal Dopaminergic Systems
An endogenous cannabinoid as an endothelium-derived vasorelaxant.
- M. Randall, Stephen P. H. Alexander, D. Kendall
- Biology, MedicineBiochemical and biophysical research…
- 1 December 1996
It is reported that EDHF-mediated relaxations in the rat mesenteric arterial bed are blocked by a highly selective cannabinoid receptor antagonist, SR141716A, consistent with EDHF being a cannabinoid-like substance, and anandamide is a potent vasorelaxant in the mesentery, acting via a hyperpolarizing mechanism.
The complexities of the cardiovascular actions of cannabinoids
The cardiovascular actions of cannbinoids are complex and in conscious animals, the picture is one of bradycardia followed by pressor responses, but clearly the responses to cannabinoids are dependent on the experimental conditions and synthetic cannabinoids and endocannabinoids exhibit different pharmacologies.
Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis
The data predict that the cannabinoid receptor system present in the synovium may be an important therapeutic target for the treatment of pain and inflammation associated with OA and RA.
Quantitative profiling of endocannabinoids and related compounds in rat brain using liquid chromatography-tandem electrospray ionization mass spectrometry.
Cannabinoid activation of PPARα; a novel neuroprotective mechanism
The ability of a range of cannabinoids to activate PPARα and for N-oleoylethanolamine (OEA), an endogenous cannabinoid-like compound (ECL), to evoke neuroprotection is investigated.
Inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a…
Time-dependent vascular actions of cannabidiol in the rat aorta.
Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain
- S. Elmes, M. Jhaveri, D. Smart, D. Kendall, V. Chapman
- BiologyThe European journal of neuroscience
- 1 November 2004
It is demonstrated that activation of peripheral CB2 receptors attenuates both innocuous‐ and noxious‐evoked responses of WDR neurons in models of acute, inflammatory and neuropathic pain.
Analgesic Effects of Fatty Acid Amide Hydrolase Inhibition in a Rat Model of Neuropathic Pain
- M. Jhaveri, D. Richardson, D. Kendall, D. Barrett, V. Chapman
- BiologyThe Journal of Neuroscience
- 20 December 2006
Spinal administration of URB597 attenuated evoked responses of spinal neurons and elevated levels of endocannabinoids in sham-operated and SNL rats suggest that peripheral FAAH activity may be altered or that alternative pathways of metabolism have greater importance in SNL Rats.