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The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor α in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes
TLDR
PGC-1 coactivators: inducible regulators of energy metabolism in health and disease.
TLDR
The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus.
- B. Finck, J. J. Lehman, D. Kelly
- Biology, MedicineThe Journal of clinical investigation
- 2002
TLDR
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function.
- D. Kelly, R. Scarpulla
- BiologyGenes & development
- 15 February 2004
TLDR
Transcriptional integration of mitochondrial biogenesis
- R. Scarpulla, R. Vega, D. Kelly
- BiologyTrends in Endocrinology & Metabolism
- 1 September 2012
Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis.
- J. J. Lehman, P. Barger, A. Kovács, J. Saffitz, D. Medeiros, D. Kelly
- BiologyThe Journal of clinical investigation
- 1 October 2000
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Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC‐1
- K. Baar, A. Wende, J. Holloszy
- BiologyFASEB journal : official publication of the…
- 1 December 2002
TLDR
Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1
- L. F. Michael, Zhidan Wu, B. Spiegelman
- BiologyProceedings of the National Academy of Sciences…
- 13 March 2001
TLDR
PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis
- T. Leone, J. J. Lehman, D. Kelly
- BiologyPLoS biology
- 15 March 2005
TLDR
Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.
- B. Finck, Matthew C. Gropler, D. Kelly
- BiologyCell metabolism
- 2006
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