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The pharmacological characterization of a novel selective 5-hydroxytryptamine1A receptor antagonist, NAD-299.
The pharmacological properties of a novel selective 5-hydroxytryptamine1A (5-HT1A) receptor antagonist, NAD-299 [(R)-3-N,N-dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamideExpand
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Release of 3H-noradrenaline from the rat vas deferens under various in vitro conditions.
The release of 3H-(-)-noradrenaline (NA) from rat vas deferens in vitro was examined under various experimental conditions. It was found that in normal and reserpinized vas deferens the release of NAExpand
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Inhibition of 3H-dopamine accumulation in reserpinized and normal rat striatum.
  • S. Ross, D. Kelder
  • Chemistry, Medicine
  • Acta pharmacologica et toxicologica
  • 13 March 2009
The inhibitory potencies of 27 compounds on the accumulation of 3H-dopamine (DA) in synaptosome-rich striatal homogenates of normal and reserpinized rats were determined. It was found that someExpand
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The pharmacological profile of (R)-3,4-dihydro-N-isopropyl-3-(N-isopropyl-N-propylamino)-2H-1-benzopyran-5-carboxamide, a selective 5-hydroxytryptamine(1A) receptor agonist.
The pharmacological properties of the 5-hydroxytryptamine (HT)(1A) receptor agonist (R)-3,4-dihydro-N-isopropyl-3-(N-isopropyl-N-propylamino)-2H-1-benzopyran-5-carboxamide (NAE-086) were examinedExpand
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Effect of veratridine on the fluxes of 3H-noradrenaline and 3H-bretylium in the rat vas deferens in vitro
  • S. Ross, D. Kelder
  • Chemistry, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • 1 December 1976
SummaryThe effect of the depolarizing agent veratridine on the accumulation and release of 3H-noradrenaline and 3H-bretylium in the rat vas deferens in vitro was examined. Veratridine producedExpand
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Active transport of 3H-bretylium in the rat vas deferens in vitro.
The uptake and efflux of 3H-bretylium in slices of the rat vas deferens were examined. The uptake of bretylium was temperature, Na+ and Cl- dependent, sensitive to 6-hydroxydopamine but insensitiveExpand
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Efflux of 5-hydroxytryptamine from synaptosomes of rat cerebral cortex.
The efflux of 3H-5-HT from a crude synaptosome preparation of the cerebral cortex of reserpinized rats was examined. The synaptosomes were loaded with 3H-5-HT by pre-incubation of the homogenate inExpand
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Effects of acute and repeated administration of amiflamine on monoamine oxidase inhibition in the rat.
The inhibitory effect on monoamine oxidase (MAO) of the reversible MAO-A inhibitor (+)-4-dimethylamino-2,alpha-dimethylphenethylamine [amiflamine, FLA 336(+)] was evaluated in the rat after acute andExpand
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Evoked efflux of 3H-bretylium by sympathomimetic amines from the rat vas deferens in vitro.
  • S. Ross, D. Kelder
  • Chemistry, Medicine
  • Acta pharmacologica et toxicologica
  • 13 March 2009
The efflux of 3H-bretylium in rat vas deferens in vitro evoked by a number of sympathomimetic amines was examined. The tissue was preloaded with 3H-bretylium (2 x 10(-7) M) and the efflux ofExpand
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α1 (but not α2)-Adrenoceptor Agonists in Combination with the Dopamine D2 Agonist Quinpirole Produce Locomotor Stimulation in Dopamine-Depleted Mice
Mice were premedicated with reserpine and alpha-methyl-p-tyrosine to deplete stores of dopamine (DA) (and other neurotransmitters) and to stop DA (and noradrenaline (NA] synthesis. In DA-depletedExpand
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