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Activity-based probes that target diverse cysteine protease families
Proteases are one of the largest and best-characterized families of enzymes in the human proteome. Unfortunately, the understanding of protease function in the context of complex proteolytic cascades… Expand
Paranodal dissection in chronic inflammatory demyelinating polyneuropathy with anti-neurofascin-155 and anti-contactin-1 antibodies
- H. Koike, M. Kadoya, +10 authors G. Sobue
- Journal of Neurology, Neurosurgery & Psychiatry
- 10 January 2017
Objective To investigate the morphological features of chronic inflammatory demyelinating polyneuropathy (CIDP) with autoantibodies directed against paranodal junctional molecules, particularly… Expand
Dual microglia effects on blood brain barrier permeability induced by systemic inflammation
Microglia survey brain parenchyma, responding to injury and infections. Microglia also respond to systemic disease, but the role of blood–brain barrier (BBB) integrity in this process remains… Expand
Microglia Enhance Synapse Activity to Promote Local Network Synchronization
Visual Abstract Microglia are highly motile immunoreactive cells that play integral roles in the response to brain infection and damage, and in the progression of various neurological diseases.… Expand
Procalcitonin as a useful biomarker for determining the need to perform emergency biliary drainage in cases of acute cholangitis
- Satoshi Shinya, Takamitsu Sasaki, +5 authors T. Noritomi
- Journal of hepato-biliary-pancreatic sciences
- 1 October 2014
It is important to identify biomarkers for sepsis and organ damage in acute cholangitis patients. We investigated the usefulness of procalcitonin (PCT) as a biomarker of inflammation based on the… Expand
Voxel‐based quantitative susceptibility mapping in Parkinson's disease with mild cognitive impairment
- Y. Uchida, H. Kan, +5 authors N. Matsukawa
- Movement disorders : official journal of the…
- 1 August 2019
Brain iron accumulation has been proposed as one of the pathomechanisms in Parkinson's disease (PD). This study aimed to examine the whole‐brain pattern of iron accumulation associated with cognitive… Expand
Contaminated drainage fluid and pancreatic fistula after pancreatoduodenectomy: A retrospective study.
BACKGROUND Appropriate bacterial infection control in the perioperative period of a pancreaticoduodenectomy (PD) is important to prevent and manage serious complications including postoperative… Expand
Photochromism of a radical diffusion-inhibited hexaarylbiimidazole derivative with intense coloration and fast decoloration performance.
We report the synthesis and the photochromic behavior of a newly designed, photochromic, radical diffusion-inhibited hexaarylbiimidazole (HABI) derivative with markedly improved photochromic… Expand
Randomized prospective study on prophylactic antibiotics in clean orthopedic surgery in one ward for 1 year
- D. Kato, K. Maezawa, +4 authors H. Kurosawa
- Journal of orthopaedic science : official journal…
BackgroundAt present in Japan, there are neither reports on antibiotic prophylaxis regardless of underlying diseases nor precise guidelines on prophylactic antibiotics in orthopedic surgery.… Expand
A general solid phase method for the preparation of diverse azapeptide probes directed against cysteine proteases.
[chemical reaction: see text]. A solid phase approach is presented for the synthesis of azapeptide inhibitors and activity based probes (ABPs) for cysteine proteases. This synthetic method allows the… Expand