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Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome".
- H. Tettelin, V. Masignani, C. Fraser
- BiologyProceedings of the National Academy of Sciences…
- 27 September 2005
The genomic sequence of six strains representing the five major disease-causing serotypes of Streptococcus agalactiae, the main cause of neonatal infection in humans, was generated and Mathematical extrapolation of the data suggests that the gene reservoir available for inclusion in the S. agalactic pan-genome is vast and that unique genes will continue to be identified even after sequencing hundreds of genomes.
A microbial symbiosis factor prevents intestinal inflammatory disease
It is reported here that the prominent human symbiont Bacteroides fragilis protects animals from experimental colitis induced by Helicobacter hepaticus and that molecules of the bacterial microbiota can mediate the critical balance between health and disease.
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae
- H. Tettelin, V. Masignani, C. Fraser
- Biology, EngineeringProceedings of the National Academy of Sciences…
- 28 August 2002
In silico analyses, combined with comparative genome hybridization experiments between the sequenced serotype V strain 2603 V/R and 19 S. agalactiae strains from several serotypes using whole-genome microarrays, revealed the genetic heterogeneity among S. agriculture, provided insights into the evolution of virulence mechanisms.
Serotypes VI and VIII predominate among group B streptococci isolated from pregnant Japanese women.
Data show that type VI and VIII GBS strains are common vaginal isolates in pregnant Japanese women and that one or more laddering proteins are present in most G BS strains.
Small Molecule Control of Virulence Gene Expression in Francisella tularensis
- James C. Charity, Leeann T Blalock, Michelle M. Costante-Hamm, D. Kasper, S. Dove
- BiologyPLoS pathogens
- 1 October 2009
It is shown that in the live vaccine strain of F. tularensis (LVS), the MglA-SspA complex works in concert with a putative DNA-binding protein, called PigR, together with the alarmone guanosine tetraphosphate (ppGpp), to regulate the expression of target genes.
Functional Analysis in Type Ia Group B Streptococcusof a Cluster of Genes Involved in Extracellular Polysaccharide Production by Diverse Species of Streptococci*
- M. Cieslewicz, D. Kasper, Ying Wang, M. Wessels
- BiologyThe Journal of Biological Chemistry
- 5 January 2001
It is concluded that CpsA to -D are not required for polysaccharide repeating unit biosynthesis but rather that they direct the coordinated polymerization and export of high molecular weight poly Saccharide.
Regulation of Virulence by a Two-Component System in Group B Streptococcus
The characterization of a GBS locus that encodes a two-component regulatory system similar to CsrRS (or CovRS) in Streptococcus pyogenes is reported, indicating that CSRRS regulates expression of multiple GBS virulence determinants and is likely to play an important role in GBS pathogenesis.
Structural and Genetic Diversity of Group B Streptococcus Capsular Polysaccharides
Striking heterogeneity in amino acid sequences of synthetic enzymes with very similar functions is found that supports horizontal gene transfer rather than stepwise mutagenesis as a mechanism for capsule variation, and suggests that the evolutionary pressure toward antigenic variation exerted by acquired immunity is counterbalanced by a survival advantage conferred by conserved structural motifs of the GBS polysaccharides.
A Mechanism for Neurodegeneration Induced by Group B Streptococci through Activation of the TLR2/MyD88 Pathway in Microglia1
A causal molecular relationship between infection with GBS, activation of the innate immune system in the CNS through TLR2, and neurodegeneration is demonstrated and is suggested that this process contributes substantially to the serious morbidity associated with neonatal GBS meningitis and may provide a potential therapeutic target.