D. Kaplan

Publications1,552
h-index150
Citations100,942
Highly Influential Citations1,683
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Porosity of 3D biomaterial scaffolds and osteogenesis.
TLDR
New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs. Expand
Silk-based biomaterials.
TLDR
Studies with well-defined silkworm silk fibers and films suggest that the core silk fibroin fibers exhibit comparable biocompatibility in vitro and in vivo with other commonly used biomaterials such as polylactic acid and collagen. Expand
Silk as a Biomaterial.
TLDR
Silks are fibrous proteins with remarkable mechanical properties produced in fiber form by silkworms and spiders that are biocompatible when studied in vitro and in vivo. Expand
Villification: How the Gut Gets Its Villi
TLDR
A quantitative computational model, incorporating measured properties of the developing gut, recapitulates the morphological patterns seen during villification in a variety of species, providing a mechanistic understanding of the formation of these elaborations of the lining of the gut, essential for providing sufficient surface area for nutrient absorption. Expand
Electrospun silk-BMP-2 scaffolds for bone tissue engineering.
TLDR
Electrospun silk-fibroin-based scaffolds are potential candidates for bone tissue engineering and the mild aqueous process required to spin the fibers offers an important option for delivery of labile cytokines and other components into the system. Expand
Materials fabrication from Bombyx mori silk fibroin
TLDR
This protocol includes methods to extract silk from B. mori cocoons to fabricate hydrogels, tubes, sponges, composites, fibers, microspheres and thin films, used directly as biomaterials for implants, as scaffolding in tissue engineering and in vitro disease models, as well as for drug delivery. Expand
Silk matrix for tissue engineered anterior cruciate ligaments.
TLDR
The results support the conclusion that properly prepared silkworm fiber matrices, aside from providing unique benefits in terms of mechanical properties as well as biocompatibility and slow degradability, can provide suitable biomaterial matrices for the support of adult stem cell differentiation toward ligament lineages. Expand
Bone Tissue Engineering Using Human Mesenchymal Stem Cells: Effects of Scaffold Material and Medium Flow
TLDR
It is suggested that osteogenesis in cultured MSC can be modulated by scaffold properties and flow environment. Expand
Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics.
TLDR
A material strategy for a type of bio-interfaced system that relies on ultrathin electronics supported by bioresorbable substrates of silk fibroin that provides new capabilities for implantable and surgical devices is described. Expand
Tissue engineering of ligaments.
TLDR
One representative tissue engineering system involving the integrated use of adult human stem cells, custom-designed scaffolds, and advanced bioreactors with dynamic loading is described and focuses on the tissue engineering of ligaments. Expand
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