Porosity of 3D biomaterial scaffolds and osteogenesis.
Silk as a Biomaterial.
Materials fabrication from Bombyx mori silk fibroin
- D. Rockwood, R. C. Preda, Tuna Yücel, Xiaoqin Wang, Michael L. Lovett, D. Kaplan
- Medicine, Materials ScienceNature Protocols
- 1 September 2011
This protocol includes methods to extract silk from B. mori cocoons to fabricate hydrogels, tubes, sponges, composites, fibers, microspheres and thin films, used directly as biomaterials for implants, as scaffolding in tissue engineering and in vitro disease models, as well as for drug delivery.
Villification: How the Gut Gets Its Villi
A quantitative computational model, incorporating measured properties of the developing gut, recapitulates the morphological patterns seen during villification in a variety of species, providing a mechanistic understanding of the formation of these elaborations of the lining of the gut, essential for providing sufficient surface area for nutrient absorption.
Electrospun silk-BMP-2 scaffolds for bone tissue engineering.
Silk matrix for tissue engineered anterior cruciate ligaments.
Bone Tissue Engineering Using Human Mesenchymal Stem Cells: Effects of Scaffold Material and Medium Flow
- L. Meinel, V. Karageorgiou, G. Vunjak‐Novakovic
- Biology, MedicineAnnals of Biomedical Engineering
It is suggested that osteogenesis in cultured MSC can be modulated by scaffold properties and flow environment.
Determining Beta-Sheet Crystallinity in Fibrous Proteins by Thermal Analysis and Infrared Spectroscopy
We report a study of self-assembled beta-pleated sheets in B. mori silk fibroin films using thermal analysis and infrared spectroscopy. B. mori silk fibroin may stand as an exemplar of fibrous…
Native-sized recombinant spider silk protein produced in metabolically engineered Escherichia coli results in a strong fiber
- Xiao-Xia Xia, Zhi-Gang Qian, C. S. Ki, Y. Park, D. Kaplan, S. Lee
- BiologyProceedings of the National Academy of Sciences
- 26 July 2010
The results provide insight into evolution of silk protein size related to mechanical performance, and clarify why spinning lower molecular weight proteins does not recapitulate the properties of native fibers.