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Silk-based biomaterials.
Silk from the silkworm, Bombyx mori, has been used as biomedical suture material for centuries. The unique mechanical properties of these fibers provided important clinical repair options for manyExpand
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Electrospun silk-BMP-2 scaffolds for bone tissue engineering.
Silk fibroin fiber scaffolds containing bone morphogenetic protein 2 (BMP-2) and/or nanoparticles of hydroxyapatite (nHAP) prepared via electrospinning were used for in vitro bone formation fromExpand
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Silk matrix for tissue engineered anterior cruciate ligaments.
A silk-fiber matrix was studied as a suitable material for tissue engineering anterior cruciate ligaments (ACL). The matrix was successfully designed to match the complex and demanding mechanicalExpand
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Bone Tissue Engineering Using Human Mesenchymal Stem Cells: Effects of Scaffold Material and Medium Flow
We report studies of bone tissue engineering using human mesenchymal stem cells (MSCs), a protein substrate (film or scaffold; fast degrading unmodified collagen, or slowly degrading cross-linkedExpand
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Cell differentiation by mechanical stress
Growth factors, hormones, and other regulatory molecules are traditionally required in tissue engineering studies to direct the differentiation of progenitor cells along specific lineages. WeExpand
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Tissue engineering of ligaments.
Tissue engineering is emerging as a significant clinical option to address tissue and organ failure by implanting biological substitutes for the compromised tissues. As compared to theExpand
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Three-dimensional aqueous-derived biomaterial scaffolds from silk fibroin.
A new all-aqueous process is described to form three-dimensional porous silk fibroin matrices with control of structural and morphological features. The result of this process are scaffolds withExpand
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Stem cell-based tissue engineering with silk biomaterials.
Silks are naturally occurring polymers that have been used clinically as sutures for centuries. When naturally extruded from insects or worms, silk is composed of a filament core protein, termedExpand
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Vascularization strategies for tissue engineering.
Tissue engineering is currently limited by the inability to adequately vascularize tissues in vitro or in vivo. Expand
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Bacterial cellulose as a potential scaffold for tissue engineering of cartilage.
Tissue constructs for cartilage with native mechanical properties have not been described to date. To address this need the bacterial cellulose (BC) secreted by Gluconacetobacter xylinus (=Expand
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